Rabbit Polyclonal Anti-Corticotropin-releasing factor receptor 2 antibody (STJ98962)

$99.00$319.00

Reactivity: Human, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-Corticotropin-releasing factor receptor 2 antibody (STJ98962)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|Corticotropin releasing hormone receptor 2 antibody|Corticotropin-releasing factor receptor 2 antibody|Corticotropin-releasing hormone receptor 2 antibody|CRF 2 antibody|CRF 2R antibody|CRF R2 antibody|CRF RB antibody|CRF-R-2 antibody|CRF-R2 antibody|CRF2 antibody|CRF2 receptor beta isoform antibody|CRF2R antibody|CRFR 2 antibody|CRFR-2 antibody|CRFR2 antibody|CRFR2_HUMAN antibody|CRH 2R antibody|CRH R2 antibody|CRH-R-2 antibody|CRH-R2 antibody|CRH2R antibody|CRHR 2 antibody|Crhr2 antibody|HM CRF antibody|Anti-Corticotropin Releasing Factor Receptor 2 antibody – N-terminal (ab175568)
SCBT cat No: sc-20550|sc-1826|

Name

Anti-Corticotropin-releasing factor receptor 2 antibody

Catalogue No.

STJ98962

Reactivity

Human, Rat

Specificity

Anti-Corticotropin-releasing factor receptor 2 antibody detects endogenous Corticotropin-releasing factor receptor 2.

Immunogen

Synthetic peptide from human protein at AA range: 221-295.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

48kDa

Formulation

Anti-Corticotropin-releasing factor receptor 2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Corticotropin-releasing factor receptor 2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Corticotropin releasing hormone receptor 2 antibody, Corticotropin-releasing factor receptor 2 antibody, Corticotropin-releasing hormone receptor 2 antibody, CRF 2 antibody, CRF 2R antibody, CRF R2 antibody, CRF RB antibody, CRF-R-2 antibody, CRF-R2 antibody, CRF2 antibody, CRF2 receptor beta isoform antibody, CRF2R antibody, CRFR 2 antibody, CRFR-2 antibody, CRFR2 antibody, CRFR2_HUMAN antibody, CRH 2R antibody, CRH R2 antibody, CRH-R-2 antibody, CRH-R2 antibody, CRH2R antibody, CRHR 2 antibody, Crhr2 antibody, HM CRF antibody

Database links

UniProt/Swiss-Prot:Q13324

Protein function

G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Protein sequence and domain

Belongs to the G-protein coupled receptor 2 family. The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity). ; The uncleaved pseudo signal peptide prevents receptor’s oligomerization and coupling to G(i) subunits. It is also responsible for the rather low receptor localization at the plasma membrane (PubMed:22689579).

Protein post-translational modifications

A N-glycosylation site within the signal peptide impedes its proper cleavage and function. .

Protein cellular localization

Cell membrane ; Multi-pass membrane protein .

Research area

All research areas>Neurobiology>CRF-R
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize Anti-Corticotropin-releasing factor receptor 2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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