Rabbit Polyclonal Anti-CYCS antibody (STJ98953)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-CYCS antibody (STJ98953)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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SCBT cat No:

Name

Anti-CYCS antibody

Catalogue No.

STJ98953

Reactivity

Human, Mouse, Rat

Specificity

Anti-CYCS antibody detects endogenous CYCS.

Immunogen

Synthetic peptide from human protein at AA range: 1-69.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

15kDa

Formulation

Anti-CYCS antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-CYCS antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Database links

UniProt/Swiss-Prot:P99999

Protein function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Involvement in disease

Thrombocytopenia 4 (THC4) [MIM:612004]: Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the cytochrome c family.

Protein post-translational modifications

Binds 1 heme group per subunit.; Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. .

Protein cellular localization

Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.

Note

AntibodyPlus can customize Anti-CYCS antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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Immunohistochemical analysis of paraffin embedded Mouse lung tissue

 

Immunohistochemical analysis of paraffin embedded Mouse heart tissue

 

Immunohistochemical analysis of paraffin embedded Rat kidney tissue

 

Immunohistochemical analysis of paraffin embedded Rat lung tissue

 

Immunohistochemical analysis of paraffin embedded Rat heart tissue

 

Immunofluorescence analysis of Rat spleen tissue

 

Immunofluorescence analysis of Rat spleen tissue

 

Immunofluorescence analysis of Rat lung tissue

 

Immunofluorescence analysis of Rat lung tissue

 

Immunofluorescence analysis of Mouse spleen tissue

 

Immunofluorescence analysis of Mouse spleen tissue

 

Immunohistochemical analysis of paraffin embedded Mouse kidney tissue



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