Rabbit Polyclonal Anti-DAAM1 antibody (STJ98677)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-DAAM1 antibody (STJ98677)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:5000-20000

Recommended protocols: check protocols

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SCBT cat No:

Name

Anti-DAAM1 antibody

Catalogue No.

STJ98677

Reactivity

Human, Mouse

Specificity

Anti-DAAM1 antibody detects endogenous DAAM1.

Immunogen

Synthetic peptide from human protein at AA range: 400-500.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

123kDa

Formulation

Anti-DAAM1 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-DAAM1 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Database links

UniProt/Swiss-Prot:Q9Y4D1

Protein function

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). .

Protein tissue specificity

Expressed in all tissues examined.

Protein sequence and domain

Belongs to the formin homology family. ; Contains 1 DAD (diaphanous autoregulatory) domain. ; Contains 1 FH1 (formin homology 1) domain. ; Contains 1 FH2 (formin homology 2) domain. ; Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus.; The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).

Protein cellular localization

Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Note=Perinuclear.

Note

AntibodyPlus can customize Anti-DAAM1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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