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Rabbit Polyclonal Anti-E2F-1 (Acetyl K117) antibody (STJ98838)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:5000-20008
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) antibody|ADP ribosyltransferase diphtheria toxin like 1 antibody|ADP ribosyltransferase NAD(+) antibody|ADPRT 1 antibody|ADPRT antibody|ADPRT1 antibody|ARTD1 antibody|msPARP antibody|NAD(+) ADP ribosyltransferase 1 antibody|NAD(+) ADP-ribosyltransferase 1 antibody|pADPRT 1 antibody|pADPRT1 antibody|PARP 1 antibody|PARP antibody|PARP-1 antibody|PARP1 antibody|PARP1_HUMAN antibody|Poly (ADP ribose) polymerase 1 antibody|poly (ADP ribose) polymerase family, member 1 antibody|Poly [ADP-ribose] polymerase 1 antibody|Poly(ADP ribose) polymerase antibody|poly(ADP ribose) synthetase antibody|poly(ADP ribosyl)transferase antibody|Poly[ADP ribose] synthetase 1 antibody|Poly[ADP-ribose] synthase 1 antibody|PPOL antibody|Anti-PARP antibody [E102] (ab32138)
SCBT cat No: sc-23461|sc-56196|sc-56217|sc-52953|sc-71965|sc-23465|sc-23464|sc-23335|sc-73850|sc-49413|sc-49414|sc-393134|sc-390005|
Anti-E2F-1 (Acetyl K117) antibody
|Catalogue No.|| |
Human, Mouse, Rat
Anti-E2F-1 (Acetyl K117) antibody detects endogenous levels of PARP-1 (Acetyl-K521). It doesn’t reacte with total protein.
Synthesized Acetyl peptide derived from Human PARP-1 at AA range: K521.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:5000-20008
Anti-E2F-1 (Acetyl K117) antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-E2F-1 (Acetyl K117) antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) antibody, ADP ribosyltransferase diphtheria toxin like 1 antibody, ADP ribosyltransferase NAD(+) antibody, ADPRT 1 antibody, ADPRT antibody, ADPRT1 antibody, ARTD1 antibody, msPARP antibody, NAD(+) ADP ribosyltransferase 1 antibody, NAD(+) ADP-ribosyltransferase 1 antibody, pADPRT 1 antibody, pADPRT1 antibody, PARP 1 antibody, PARP antibody, PARP-1 antibody, PARP1 antibody, PARP1_HUMAN antibody, Poly (ADP ribose) polymerase 1 antibody, poly (ADP ribose) polymerase family, member 1 antibody, Poly [ADP-ribose] polymerase 1 antibody, Poly(ADP ribose) polymerase antibody, poly(ADP ribose) synthetase antibody, poly(ADP ribosyl)transferase antibody, Poly[ADP ribose] synthetase 1 antibody, Poly[ADP-ribose] synthase 1 antibody, PPOL antibody
|Database links|| |
|Protein function|| |
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (PubMed:17177976). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of histones in a HPF1-dependent manner (PubMed:27067600). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). .
|Protein sequence and domain|| |
Contains 1 BRCT domain. ; Contains 1 PARP alpha-helical domain. ; Contains 1 PARP catalytic domain. ; Contains 2 PARP-type zinc fingers.
|Protein post-translational modifications|| |
Phosphorylated by PRKDC and TXK. .; Poly-ADP-ribosylated by PARP2. Poly-ADP-ribosylation mediates the recruitment of CHD1L to DNA damage sites.; S-nitrosylated, leading to inhibit transcription regulation activity. .
|Protein cellular localization|| |
Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage.
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St John’s Laboratory Ltd.
|Product type|| |
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