Rabbit Polyclonal Anti-ERK1 antibody (STJ98942)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-ERK1 antibody (STJ98942)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|ERK 1 antibody|Extracellular signal-regulated kinase 1 antibody|HGNC6877 antibody|HS44KDAP antibody|HUMKER1A antibody|Insulin Stimulated MAP2 Kinase antibody|Insulin-stimulated MAP2 kinase antibody|MAP kinase 1 antibody|MAP kinase 3 antibody|MAP Kinase antibody|MAP kinase isoform p44 antibody|MAPK 1 antibody|MAPK 3 antibody|MAPK antibody|MAPK1 antibody|Mapk3 antibody|MGC20180 antibody|Microtubule Associated Protein 2 Kinase antibody|Microtubule-associated protein 2 kinase antibody|Mitogen Activated Protein Kinase 3 antibody|Mitogen-activated protein kinase 1 antibody|Mitogen-activated protein kinase 3 antibody|MK03_HUMAN antibody|OTTHUMP00000174538 antibody|OTTHUMP00000174541 antibody|p44 ERK1 antibody|p44 MAPK antibody|p44-ERK1 antibody|p44-MAPK antibody|P44ERK1 antibody|P44MAPK antibody|PRKM 3 antibody|PRKM3 antibody|Protein Kinase Mitogen Activated 3 antibody|Anti-ERK1 + ERK2 antibody (ab17942)
SCBT cat No: sc-81457|sc-136288|sc-65981|sc-81458|sc-81459|sc-154|sc-271458|sc-1647|sc-271451|sc-153|sc-365234|sc-155|sc-374239|

Name

Anti-ERK1 antibody

Catalogue No.

STJ98942

Reactivity

Human, Mouse, Rat

Specificity

Anti-ERK1 antibody detects endogenous ERK1 protein.

Immunogen

Recombinant Protein of ERK1.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

44kDa

Formulation

Anti-ERK1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-ERK1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

ERK 1 antibody, Extracellular signal-regulated kinase 1 antibody, HGNC6877 antibody, HS44KDAP antibody, HUMKER1A antibody, Insulin Stimulated MAP2 Kinase antibody, Insulin-stimulated MAP2 kinase antibody, MAP kinase 1 antibody, MAP kinase 3 antibody, MAP Kinase antibody, MAP kinase isoform p44 antibody, MAPK 1 antibody, MAPK 3 antibody, MAPK antibody, MAPK1 antibody, Mapk3 antibody, MGC20180 antibody, Microtubule Associated Protein 2 Kinase antibody, Microtubule-associated protein 2 kinase antibody, Mitogen Activated Protein Kinase 3 antibody, Mitogen-activated protein kinase 1 antibody, Mitogen-activated protein kinase 3 antibody, MK03_HUMAN antibody, OTTHUMP00000174538 antibody, OTTHUMP00000174541 antibody, p44 ERK1 antibody, p44 MAPK antibody, p44-ERK1 antibody, p44-MAPK antibody, P44ERK1 antibody, P44MAPK antibody, PRKM 3 antibody, PRKM3 antibody, Protein Kinase Mitogen Activated 3 antibody

Database links

UniProt/Swiss-Prot:P27361

Protein function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. .

Protein sequence and domain

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. ; Contains 1 protein kinase domain. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Protein post-translational modifications

Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204. .

Protein cellular localization

Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization.

Research area

All research areas>Kinases and Phosphatases>ERK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Anti-ERK1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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