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Rabbit Polyclonal Anti-FAS-L antibody (STJ99000)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|ALPS1B antibody|Apoptosis (APO 1) antigen ligand 1 antibody|Apoptosis antigen ligand 1 antibody|Apoptosis antigen ligand antibody|APT1LG1 antibody|APTL antibody|CD178 antibody|CD178 antigen antibody|CD95 ligand antibody|CD95-L antibody|CD95L antibody|CD95L protein antibody|Fas antigen ligand antibody|Fas L antibody|Fas ligand (TNF superfamily member 6) antibody|Fas ligand antibody|FASL antibody|Fasl Fas ligand (TNF superfamily member 6) antibody|FASLG antibody|Generalized lymphoproliferative disease antibody|Gld antibody|soluble form antibody|TNFL6_HUMAN antibody|TNFSF6 antibody|Tumor necrosis factor (ligand) superfamily member 6 antibody|Tumor necrosis factor ligand superfamily member 6 antibody|Anti-Fas Ligand antibody (ab15285)
SCBT cat No: sc-19988|
|Catalogue No.|| |
Anti-FAS-L antibody detects endogenous FAS-L .
Synthetic peptide from human protein at AA range: 121-170.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
Anti-FAS-L antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-FAS-L antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ALPS1B antibody, Apoptosis (APO 1) antigen ligand 1 antibody, Apoptosis antigen ligand 1 antibody, Apoptosis antigen ligand antibody, APT1LG1 antibody, APTL antibody, CD178 antibody, CD178 antigen antibody, CD95 ligand antibody, CD95-L antibody, CD95L antibody, CD95L protein antibody, Fas antigen ligand antibody, Fas L antibody, Fas ligand (TNF superfamily member 6) antibody, Fas ligand antibody, FASL antibody, Fasl Fas ligand (TNF superfamily member 6) antibody, FASLG antibody, Generalized lymphoproliferative disease antibody, Gld antibody, soluble form antibody, TNFL6_HUMAN antibody, TNFSF6 antibody, Tumor necrosis factor (ligand) superfamily member 6 antibody, Tumor necrosis factor ligand superfamily member 6 antibody
|Database links|| |
|Protein function|| |
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. .; The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition. .
|Involvement in disease|| |
Autoimmune lymphoproliferative syndrome 1B (ALPS1B) [MIM:601859]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the tumor necrosis factor family.
|Protein post-translational modifications|| |
The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells. .; N-glycosylated.; Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization. .; Monoubiquitinated.
|Protein cellular localization|| |
Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane.; Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted . Note=May be released into the extracellular fluid, probably by cleavage form the cell surface. .; FasL intracellular Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus.
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St John’s Laboratory Ltd.
|Product type|| |
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