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Rabbit Polyclonal Anti-FIG4 antibody (STJ98855)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:5000-20025
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-FIG4 antibody.
Check alternative names for the antibodyExpand
|5-bisphosphate 5-phosphatase antibody|ALS 11 antibody|ALS11 antibody|CMT4J antibody|dJ249I4. antibody|Fig4 antibody|FIG4 homolog (S cerevisiae) antibody|FIG4 homolog antibody|FIG4 homolog SAC domain containing lipid phosphatase antibody|FIG4 homolog SAC1 lipid phosphatase domain containing antibody|FIG4 homolog, SAC1 lipid phosphatase domain containing (S cerevisiae antibody|FIG4_HUMAN antibody|KIAA0274 antibody|phosphatidylinositol 3 5 bisphosphate 5 phosphatase antibody|Phosphatidylinositol 3 antibody|Phosphatidylinositol 3,5 bisphosphate 5 phosphatase antibody|Polyphosphoinositide phosphatase antibody|RP1-249I4.1 antibody|SAC 3 antibody|Sac domain containing inositol phosphatase 3 antibody|SAC domain containing protein 3 antibody|SAC domain-containing protein 3 antibody|SAC3 antibody|YVS antibody|Anti-FIG4 antibody [S202-7] – C-terminal (ab186269)
SCBT cat No: sc-98633|
|Catalogue No.|| |
Anti-FIG4 antibody detects endogenous levels of FIG4.
Synthesized peptide derived from Human FIG4 at AA range: 341-390.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:5000-20025
Anti-FIG4 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-FIG4 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
5-bisphosphate 5-phosphatase antibody, ALS 11 antibody, ALS11 antibody, CMT4J antibody, dJ249I4. antibody, Fig4 antibody, FIG4 homolog (S cerevisiae) antibody, FIG4 homolog antibody, FIG4 homolog SAC domain containing lipid phosphatase antibody, FIG4 homolog SAC1 lipid phosphatase domain containing antibody, FIG4 homolog, SAC1 lipid phosphatase domain containing (S cerevisiae antibody, FIG4_HUMAN antibody, KIAA0274 antibody, phosphatidylinositol 3 5 bisphosphate 5 phosphatase antibody, Phosphatidylinositol 3 antibody, Phosphatidylinositol 3,5 bisphosphate 5 phosphatase antibody, Polyphosphoinositide phosphatase antibody, RP1-249I4.1 antibody, SAC 3 antibody, Sac domain containing inositol phosphatase 3 antibody, SAC domain containing protein 3 antibody, SAC domain-containing protein 3 antibody, SAC3 antibody, YVS antibody
|Database links|| |
|Protein function|| |
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. .
|Involvement in disease|| |
Charcot-Marie-Tooth disease 4J (CMT4J) [MIM:611228]: A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Amyotrophic lateral sclerosis 11 (ALS11) [MIM:612577]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Yunis-Varon syndrome (YVS) [MIM:216340]: A severe autosomal recessive disorder characterized by skeletal defects, including cleidocranial dysplasia and digital anomalies, and severe neurologic involvement with neuronal loss. Enlarged cytoplasmic vacuoles are found in neurons, muscle, and cartilage. The disorder is usually lethal in infancy. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Polymicrogyria, bilateral temporooccipital (BTOP) [MIM:612691]: A disease characterized by temporo-occipital polymicrogyria, psychiatric manifestations, and epilepsy. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 SAC domain.
|Protein cellular localization|| |
Endosome membrane . Note=Localization requires VAC14 and PIKFYVE.
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St John’s Laboratory Ltd.
|Product type|| |
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