Rabbit Polyclonal Anti-FoxO3A antibody (STJ98841)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-FoxO3A antibody (STJ98841)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:5000-20011

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|B cell receptor CD22 precursor antibody|B lymphocyte cell adhesion molecule antibody|B-cell receptor CD22 antibody|B-lymphocyte cell adhesion molecule antibody|BL CAM antibody|BL-CAM antibody|BLCAM antibody|CD 22 antibody|CD22 antibody|CD22 antigen antibody|CD22 molecule antibody|CD22 protein antibody|CD22_HUMAN antibody|Lectin 2 antibody|Leu14 antibody|Lyb8 antibody|MGC130020 antibody|sialic acid binding Ig like lectin 2 antibody|Sialic acid binding immunoglobulin like lectin 2 antibody|Sialic acid-binding Ig-like lectin 2 antibody|SIGLEC 2 antibody|Siglec-2 antibody|SIGLEC2 antibody|T cell surface antigen Leu 14 antibody|T-cell surface antigen Leu-14 antibody|Anti-CD22 antibody [2H1C4] (ab181771)
SCBT cat No: sc-53031|sc-53032|

Name

Anti-FoxO3A antibody

Catalogue No.

STJ98841

Reactivity

Human

Specificity

Anti-FoxO3A antibody detects endogenous levels of CD22.

Immunogen

Synthesized peptide derived from Human CD22 at AA range: 780-860.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:5000-20011

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-FoxO3A antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-FoxO3A antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

B cell receptor CD22 precursor antibody, B lymphocyte cell adhesion molecule antibody, B-cell receptor CD22 antibody, B-lymphocyte cell adhesion molecule antibody, BL CAM antibody, BL-CAM antibody, BLCAM antibody, CD 22 antibody, CD22 antibody, CD22 antigen antibody, CD22 molecule antibody, CD22 protein antibody, CD22_HUMAN antibody, Lectin 2 antibody, Leu14 antibody, Lyb8 antibody, MGC130020 antibody, sialic acid binding Ig like lectin 2 antibody, Sialic acid binding immunoglobulin like lectin 2 antibody, Sialic acid-binding Ig-like lectin 2 antibody, SIGLEC 2 antibody, Siglec-2 antibody, SIGLEC2 antibody, T cell surface antigen Leu 14 antibody, T-cell surface antigen Leu-14 antibody

Database links

UniProt/Swiss-Prot:P20273

Protein function

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Protein tissue specificity

B-lymphocytes.

Protein sequence and domain

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. ; Contains 6 Ig-like C2-type (immunoglobulin-like) domains. ; Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Protein post-translational modifications

Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.; Phosphorylated on tyrosine residues by LYN. .

Protein cellular localization

Cell membrane; Single-pass type I membrane protein.

Research area

All research areas>Lymphocyte Signaling>CD22
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize Anti-FoxO3A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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