Rabbit Polyclonal Anti-FoxO4 (Acetyl Lys189) antibody (STJ98685)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-FoxO4 (Acetyl Lys189) antibody (STJ98685)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:5000-20000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Anti-FoxO4 (Acetyl Lys189) antibody.

Alternative names:

Check alternative names for the antibody

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|AFX antibody|AFX1 antibody|Afxh antibody|ALL1-fused gene from X chromosome antibody|Fork head domain transcription factor AFX1 antibody|Forkhead box O4 antibody|Forkhead box protein O4 antibody|FOXO 4 antibody|Foxo4 antibody|FOXO4_HUMAN antibody|MGC117660 antibody|MGC120490 antibody|Mixed lineage leukemia, translocated to, 7 antibody|MLLT7 antibody|Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 antibody|Myeloid/lymphoid or mixed lineage leukemia, translocated to, 7 antibody|RGD1561201 antibody|Anti-FOXO4 antibody [EPR5442] (ab128908)
SCBT cat No: sc-34903|

Name

Anti-FoxO4 (Acetyl Lys189) antibody

Catalogue No.

STJ98685

Reactivity

Human

Specificity

Anti-FoxO4 (Acetyl Lys189) antibody detects endogenous FoxO4 when Acetyl occurs at Lys189.

Immunogen

Synthetic Acetyl peptide from human protein at AA range: 189.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

55kDa

Formulation

Anti-FoxO4 (Acetyl Lys189) antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-FoxO4 (Acetyl Lys189) antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

AFX antibody, AFX1 antibody, Afxh antibody, ALL1-fused gene from X chromosome antibody, Fork head domain transcription factor AFX1 antibody, Forkhead box O4 antibody, Forkhead box protein O4 antibody, FOXO 4 antibody, Foxo4 antibody, FOXO4_HUMAN antibody, MGC117660 antibody, MGC120490 antibody, Mixed lineage leukemia, translocated to, 7 antibody, MLLT7 antibody, Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 antibody, Myeloid/lymphoid or mixed lineage leukemia, translocated to, 7 antibody, RGD1561201 antibody

Database links

UniProt/Swiss-Prot:P98177

Protein function

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. .

Protein tissue specificity

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.

Involvement in disease

Note=A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with KMT2A/MLL1. The result is a rogue activator protein.

Protein sequence and domain

Contains 1 fork-head DNA-binding domain.

Protein post-translational modifications

Acetylation by CREBBP/CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity. .; Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization. May be phosphorylated at multiple sites by NLK. .; Monoubiquitinated; monoubiquitination is induced by oxidative stress and reduced by deacetylase inhibitors; results in its relocalization to the nucleus and its increased transcriptional activity. Deubiquitinated by USP7; deubiquitination is induced by oxidative stress; enhances its interaction with USP7 and consequently, deubiquitination; increases its translocation to the cytoplasm and inhibits its transcriptional activity. Hydrogene-peroxide-induced ubiquitination and USP7-mediated deubiquitination have no major effect on its protein stability. .

Protein cellular localization

Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.

Note

AntibodyPlus can customize Anti-FoxO4 (Acetyl Lys189) antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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