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Rabbit Polyclonal Anti-Frizzled-9 antibody (STJ98754)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Frizzled-9 antibody.
Check alternative names for the antibodyExpand
|CD 349 antibody|CD 349 antigen antibody|CD349 antibody|Frizzled Drosophila homolog of 3 antibody|Frizzled homolog 9 (Drosophila) antibody|Frizzled homolog 9 antibody|Frizzled-9 antibody|Fz 9 antibody|Fz-9 antibody|FZD 3 antibody|Fzd 9 antibody|FZD3 antibody|FZD3-PEN antibody|FZD9 antibody|FZD9_HUMAN antibody|FzE6 antibody|hFz9 antibody|mfz9 antibody|Xfz9 antibody|Anti-Frizzled 9 antibody (ab61430)
SCBT cat No: sc-33509|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-Frizzled-9 antibody detects endogenous Frizzled-9.
Synthetic peptide from human protein at AA range: 1-50.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-Frizzled-9 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-Frizzled-9 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
CD 349 antibody, CD 349 antigen antibody, CD349 antibody, Frizzled Drosophila homolog of 3 antibody, Frizzled homolog 9 (Drosophila) antibody, Frizzled homolog 9 antibody, Frizzled-9 antibody, Fz 9 antibody, Fz-9 antibody, FZD 3 antibody, Fzd 9 antibody, FZD3 antibody, FZD3-PEN antibody, FZD9 antibody, FZD9_HUMAN antibody, FzE6 antibody, hFz9 antibody, mfz9 antibody, Xfz9 antibody
|Database links|| |
|Protein function|| |
Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). .
|Protein tissue specificity|| |
Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. Expressed in neural progenitor cells (PubMed:27509850). .
|Protein sequence and domain|| |
Belongs to the G-protein coupled receptor Fz/Smo family. ; Contains 1 FZ (frizzled) domain. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. ; The FZ domain is involved in binding with Wnt ligands.
|Protein post-translational modifications|| |
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. .
|Protein cellular localization|| |
Cell membrane ; Multi-pass membrane protein . Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. .
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St John’s Laboratory Ltd.
|Product type|| |
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