Rabbit Polyclonal Anti-Frizzled-9 antibody (STJ98754)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: IHC-P, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-Frizzled-9 antibody (STJ98754)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC-P, ELISA

Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|CD 349 antibody|CD 349 antigen antibody|CD349 antibody|Frizzled Drosophila homolog of 3 antibody|Frizzled homolog 9 (Drosophila) antibody|Frizzled homolog 9 antibody|Frizzled-9 antibody|Fz 9 antibody|Fz-9 antibody|FZD 3 antibody|Fzd 9 antibody|FZD3 antibody|FZD3-PEN antibody|FZD9 antibody|FZD9_HUMAN antibody|FzE6 antibody|hFz9 antibody|mfz9 antibody|Xfz9 antibody|Anti-Frizzled 9 antibody (ab61430)
SCBT cat No: sc-33509|

Name

Anti-Frizzled-9 antibody

Catalogue No.

STJ98754

Reactivity

Human, Mouse, Rat

Specificity

Anti-Frizzled-9 antibody detects endogenous Frizzled-9.

Immunogen

Synthetic peptide from human protein at AA range: 1-50.

Host

Rabbit

Applications

IHC-P, ELISA

Recommended dilution

IHC-P 1:50-300; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-Frizzled-9 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-Frizzled-9 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

CD 349 antibody, CD 349 antigen antibody, CD349 antibody, Frizzled Drosophila homolog of 3 antibody, Frizzled homolog 9 (Drosophila) antibody, Frizzled homolog 9 antibody, Frizzled-9 antibody, Fz 9 antibody, Fz-9 antibody, FZD 3 antibody, Fzd 9 antibody, FZD3 antibody, FZD3-PEN antibody, FZD9 antibody, FZD9_HUMAN antibody, FzE6 antibody, hFz9 antibody, mfz9 antibody, Xfz9 antibody

Database links

UniProt/Swiss-Prot:O00144

Protein function

Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). .

Protein tissue specificity

Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. Expressed in neural progenitor cells (PubMed:27509850). .

Protein sequence and domain

Belongs to the G-protein coupled receptor Fz/Smo family. ; Contains 1 FZ (frizzled) domain. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. ; The FZ domain is involved in binding with Wnt ligands.

Protein post-translational modifications

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. .

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. .

Research area

All research areas>Membrane Receptors>frizzled
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize Anti-Frizzled-9 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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