Rabbit Polyclonal Anti-GADD34 antibody (STJ98676)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-GADD34 antibody (STJ98676)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:5000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|Apoptosis associated protein antibody|GADD 34 antibody|Growth arrest and DNA damage inducible 34 antibody|Growth arrest and DNA damage-inducible protein GADD34 antibody|Myeloid differentiation primary response protein MyD116 homolog antibody|Ppp1r15a antibody|PR15A_HUMAN antibody|Protein phosphatase 1 regulatory (inhibitor) subunit 15A antibody|Protein phosphatase 1 regulatory subunit 15A antibody|Anti-GADD34 antibody (ab9869)
SCBT cat No: sc-825|

Name

Anti-GADD34 antibody

Catalogue No.

STJ98676

Reactivity

Human

Specificity

Anti-GADD34 antibody detects endogenous GADD34.

Immunogen

Synthetic peptide from human protein at AA range: 430-490.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

73kDa

Formulation

Anti-GADD34 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-GADD34 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Apoptosis associated protein antibody, GADD 34 antibody, Growth arrest and DNA damage inducible 34 antibody, Growth arrest and DNA damage-inducible protein GADD34 antibody, Myeloid differentiation primary response protein MyD116 homolog antibody, Ppp1r15a antibody, PR15A_HUMAN antibody, Protein phosphatase 1 regulatory (inhibitor) subunit 15A antibody, Protein phosphatase 1 regulatory subunit 15A antibody

Database links

UniProt/Swiss-Prot:O75807

Protein function

Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on ‘Ser-15’. .

Protein sequence and domain

Belongs to the PPP1R15 family.

Protein post-translational modifications

Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Phosphorylation at Tyr-262 enhances proteasomal degradation, this position is dephosphorylated by PTPN2. .; Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association. .

Protein cellular localization

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side . Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side . Note=Associates with membranes via an N-terminal amphipathic intramembrane region. .

Research area

All research areas>Tumor Suppressor/Apoptosis>GADD
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize Anti-GADD34 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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