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Rabbit Polyclonal Anti-GCK/GLK antibody (STJ99334)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-GCK/GLK antibody.
Check alternative names for the antibodyExpand
|B lymphocyte serine/threonine protein kinase antibody|B lymphocyte serine/threonine-protein kinase antibody|BL44 antibody|GC kinase antibody|GCK antibody|Germinal center kinase antibody|germinal centre kinase (GC kinase) antibody|M4K2_HUMAN antibody|Map4k2 antibody|MAPK/ERK kinase kinase kinase 2 antibody|MEK kinase kinase 2 antibody|MEKKK 2 antibody|Mitogen activated protein kinase kinase kinase kinase 2 antibody|Mitogen-activated protein kinase kinase kinase kinase 2 antibody|Rab8 interacting protein antibody|Rab8 interacting protein, formerly antibody|Rab8-interacting protein antibody|RAB8IP antibody|RAB8IP, formerly antibody|Anti-Germinal Center Kinase antibody [EPR14304] (ab184169)
SCBT cat No: sc-398967|sc-6161|
|Catalogue No.|| |
Anti-GCK/GLK antibody detects endogenous levels of GCK/GLK.
Synthesized peptide derived from human GCK/GLK. at AA range: 221-270.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-GCK/GLK antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-GCK/GLK antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
B lymphocyte serine/threonine protein kinase antibody, B lymphocyte serine/threonine-protein kinase antibody, BL44 antibody, GC kinase antibody, GCK antibody, Germinal center kinase antibody, germinal centre kinase (GC kinase) antibody, M4K2_HUMAN antibody, Map4k2 antibody, MAPK/ERK kinase kinase kinase 2 antibody, MEK kinase kinase 2 antibody, MEKKK 2 antibody, Mitogen activated protein kinase kinase kinase kinase 2 antibody, Mitogen-activated protein kinase kinase kinase kinase 2 antibody, Rab8 interacting protein antibody, Rab8 interacting protein, formerly antibody, Rab8-interacting protein antibody, RAB8IP antibody, RAB8IP, formerly antibody
|Database links|| |
|Protein function|| |
Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. .
|Protein tissue specificity|| |
Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. ; Contains 1 CNH domain. ; Contains 1 protein kinase domain. The PEST domains are Pro-, Glu-, Ser-, and Thr-rich domains. Proteins with PEST domains are frequently targets of degradation by the ubiquitin proteasome.
|Protein post-translational modifications|| |
Polyubiquitinated through 'Lys-48'-polyubiquitin chains, allowing proteasomal turnover. Ubiquitination requires the kinase activity of MAP4K2/GCK. .; Autophosphorylated in response to tumor necrosis factor (TNF), endotoxins or proinflammatory stimuli. Autophosphorylation leads to activation.
|Protein cellular localization|| |
Cytoplasm . Basolateral cell membrane ; Peripheral membrane protein . Golgi apparatus membrane ; Peripheral membrane protein .
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St John’s Laboratory Ltd.
|Product type|| |
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