Rabbit Polyclonal Anti-GRB7 antibody (STJ98983)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-GRB7 antibody (STJ98983)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|B47 antibody|Epidermal growth factor receptor GRB 7 antibody|Epidermal growth factor receptor GRB-7 antibody|GRB7 adapter protein antibody|GRB7 antibody|GRB7_HUMAN antibody|Growth factor receptor bound protein 7 antibody|Growth factor receptor-bound protein 7 antibody|OTTHUMP00000164349 antibody|OTTHUMP00000164350 antibody|OTTHUMP00000164351 antibody|OTTHUMP00000164352 antibody|Anti-GRB7 antibody [EPR4378] (ab109618)
SCBT cat No: sc-376069|sc-373982|sc-606|sc-13954|sc-607|

Name

Anti-GRB7 antibody

Catalogue No.

STJ98983

Reactivity

Human, Mouse, Rat

Specificity

Anti-GRB7 antibody detects endogenous GRB7 .

Immunogen

Synthetic peptide from human protein at AA range: 30-100.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-GRB7 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-GRB7 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

B47 antibody, Epidermal growth factor receptor GRB 7 antibody, Epidermal growth factor receptor GRB-7 antibody, GRB7 adapter protein antibody, GRB7 antibody, GRB7_HUMAN antibody, Growth factor receptor bound protein 7 antibody, Growth factor receptor-bound protein 7 antibody, OTTHUMP00000164349 antibody, OTTHUMP00000164350 antibody, OTTHUMP00000164351 antibody, OTTHUMP00000164352 antibody

Database links

UniProt/Swiss-Prot:Q14451

Protein function

Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5’UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). .

Protein sequence and domain

Belongs to the GRB7/10/14 family. ; Contains 1 PH domain. ; Contains 1 Ras-associating domain. ; Contains 1 SH2 domain. The PH domain mediates interaction with membranes containing phosphoinositides.

Protein post-translational modifications

Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases. .

Protein cellular localization

Cytoplasm . Cell junction, focal adhesion . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic granule . Cell projection . Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. .

Research area

All research areas>Signaling Intermediates>GRB
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize Anti-GRB7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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