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Rabbit Polyclonal Anti-GSC antibody (STJ98815)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-GSC antibody.
Check alternative names for the antibodyExpand
|Goosecoid antibody|goosecoid homeobox antibody|GSC antibody|GSC_HUMAN antibody|Homeobox protein goosecoid antibody|Anti-GSC antibody (ab58352)
SCBT cat No: sc-81964|sc-22234|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-GSC antibody detects endogenous GSC.
Synthetic peptide from human protein at AA range: 207-256.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-GSC antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-GSC antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Goosecoid antibody, goosecoid homeobox antibody, GSC antibody, GSC_HUMAN antibody, Homeobox protein goosecoid antibody
|Database links|| |
|Protein function|| |
Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. .
|Involvement in disease|| |
Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities (SAMS) [MIM:602471]: An autosomal recessive developmental disorder with features of a first and second branchial arch syndrome, and with unique rhizomelic skeletal anomalies. Craniofacial abnormalities can lead to conductive hearing loss, respiratory insufficiency, and feeding difficulties. Skeletal features include bilateral humeral hypoplasia, humeroscapular synostosis, pelvic abnormalities, and proximal defects of the femora. Affected individuals may also have some features of a neurocristopathy or abnormal mesoderm development, such as urogenital anomalies, that are distinct from other branchial arch syndromes. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the paired homeobox family. Bicoid subfamily. ; Contains 1 homeobox DNA-binding domain.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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