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Rabbit Polyclonal Anti-Haptoglobin antibody (STJ98976)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Haptoglobin antibody.
Check alternative names for the antibodyExpand
|Binding peptide antibody|BP antibody|Haptoglobin alpha chain antibody|Haptoglobin alpha(1S) beta antibody|Haptoglobin alpha(2FS) beta antibody|Haptoglobin beta chain antibody|Haptoglobin, alpha polypeptide antibody|Haptoglobin, beta polypeptide antibody|HP antibody|HP2 ALPHA2 antibody|HP2ALPHA2 antibody|HPA1S antibody|HPT antibody|HPT_HUMAN antibody|MGC111141 antibody|Zonulin antibody|Anti-Haptoglobin antibody [HG-36] (ab13429)
SCBT cat No: sc-365396|sc-376893|sc-374208|sc-134464|sc-134466|sc-390962|sc-69782|sc-69783|sc-68667|
|Catalogue No.|| |
Anti-Haptoglobin antibody detects endogenous Haptoglobin .
Synthetic peptide from human protein at AA range: 300-360.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
Anti-Haptoglobin antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Haptoglobin antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Binding peptide antibody, BP antibody, Haptoglobin alpha chain antibody, Haptoglobin alpha(1S) beta antibody, Haptoglobin alpha(2FS) beta antibody, Haptoglobin beta chain antibody, Haptoglobin, alpha polypeptide antibody, Haptoglobin, beta polypeptide antibody, HP antibody, HP2 ALPHA2 antibody, HP2ALPHA2 antibody, HPA1S antibody, HPT antibody, HPT_HUMAN antibody, MGC111141 antibody, Zonulin antibody
|Database links|| |
|Protein function|| |
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. .; Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. .
|Protein tissue specificity|| |
Expressed by the liver and secreted in plasma.
|Involvement in disease|| |
Anhaptoglobinemia (AHP) [MIM:614081]: A condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Congenital haptoglobin deficiency is a risk factor for anaphylactic non-hemolytic transfusion reactions. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peptidase S1 family. ; Contains 1 peptidase S1 domain. ; Contains 2 Sushi (CCP/SCR) domains.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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