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Rabbit Polyclonal Anti-Histone H2B antibody (STJ98686)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:5000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|HIST1H2BA antibody| testis antibody|bA317E16.3 antibody|H2B antibody|H2B histone family member U antibody|H2B histone family member U testis specific antibody|H2B histone family, member U, (testis specific) antibody|H2B testis antibody|H2B1A_HUMAN antibody|H2BFU antibody|H2BT antibody|HIST1H2BA antibody|Histone 1, H2ba antibody|Histone cluster 1 H2ba antibody|Histone H2B antibody|Histone H2B testis antibody|Histone H2B type 1 A antibody|Histone H2B type 1-A antibody|Histone H2B type 1A antibody|STBP antibody|Testis specific histone H2B antibody|Testis-specific histone H2B antibody|TSH 2B antibody|TSH2B antibody|TSH2B.1 antibody|Anti-Histone H2B (testis specific) antibody (ab23913)
SCBT cat No:
Anti-Histone H2B antibody
|Catalogue No.|| |
Human, Mouse, Rat
Anti-Histone H2B antibody detects endogenous Histone H2B.
Synthetic peptide from human protein at AA range: 1-50.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:5000-20000
|Molecular weight|| |
Anti-Histone H2B antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-Histone H2B antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
HIST1H2BA antibody, testis antibody, bA317E16.3 antibody, H2B antibody, H2B histone family member U antibody, H2B histone family member U testis specific antibody, H2B histone family, member U, (testis specific) antibody, H2B testis antibody, H2B1A_HUMAN antibody, H2BFU antibody, H2BT antibody, HIST1H2BA antibody, Histone 1, H2ba antibody, Histone cluster 1 H2ba antibody, Histone H2B antibody, Histone H2B testis antibody, Histone H2B type 1 A antibody, Histone H2B type 1-A antibody, Histone H2B type 1A antibody, STBP antibody, Testis specific histone H2B antibody, Testis-specific histone H2B antibody, TSH 2B antibody, TSH2B antibody, TSH2B.1 antibody
|Database links|| |
|Protein function|| |
Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. .
|Protein tissue specificity|| |
Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells. .
|Protein sequence and domain|| |
Belongs to the histone H2B family.
|Protein post-translational modifications|| |
Monoubiquitination at Lys-36 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 ‘Lys-4’ (H3K4me) and ‘Lys-79’ (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ‘Lys-4’ and ‘Lys-79’ methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons. .; Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. .; Acetylated during spermatogenesis. Acetylated form is most abundant in spermatogonia compared to spermatocytes and round spermatids (By similarity). .; Phosphorylated at Thr-117 in spermatogonia, spermatocytes and round spermatids. .; Methylated at Lys-118 in spermatogonia, spermatocytes and round spermatids. .
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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