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Rabbit Polyclonal Anti-HLA-DQA1 antibody (STJ98824)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-HLA-DQA1 antibody.
Check alternative names for the antibodyExpand
|CD antibody|CELIAC1 antibody|DC 4 alpha chain antibody|DC alpha antibody|DQ A1 antibody|Gluten sensitive enteropathy (celiac disease) antibody|GSE antibody|HLA Class II DQ antibody|HLA class II histocompatibility antigen DQ antibody|HLA class II histocompatibility antigen DQ(1) alpha chain antibody|HLA class II histocompatibility antigen DQ(3) alpha chain antibody|HLA DCA antibody|HLA DQA antibody|HLA DQA1 antibody|HLA DQB antibody|HLA DQB1 antibody|IDDM 1 antibody|IDDM1 antibody|Leucocyte antigen DQA1 antibody|Major histocompatibility complex class II DQ alpha 1 antibody|Major histocompatibility complex class II DQ beta 1 antibody|MHC class II antigen HLA DQ beta 1 antibody|MHC class II HLA DQ alpha 1 antibody|MHC class II HLA DQ beta glycoprotein antibody|MHC DQ beta antibody|MHC HLA DQ alpha antibody|Anti-HLA-DQA1 antibody [EPR7300] (ab128959)
SCBT cat No: sc-59239|sc-65320|
|Catalogue No.|| |
Anti-HLA-DQA1 antibody detects endogenous HLA-DQA1.
Synthetic peptide from human protein at AA range: 21-70.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-HLA-DQA1 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-HLA-DQA1 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
CD antibody, CELIAC1 antibody, DC 4 alpha chain antibody, DC alpha antibody, DQ A1 antibody, Gluten sensitive enteropathy (celiac disease) antibody, GSE antibody, HLA Class II DQ antibody, HLA class II histocompatibility antigen DQ antibody, HLA class II histocompatibility antigen DQ(1) alpha chain antibody, HLA class II histocompatibility antigen DQ(3) alpha chain antibody, HLA DCA antibody, HLA DQA antibody, HLA DQA1 antibody, HLA DQB antibody, HLA DQB1 antibody, IDDM 1 antibody, IDDM1 antibody, Leucocyte antigen DQA1 antibody, Major histocompatibility complex class II DQ alpha 1 antibody, Major histocompatibility complex class II DQ beta 1 antibody, MHC class II antigen HLA DQ beta 1 antibody, MHC class II HLA DQ alpha 1 antibody, MHC class II HLA DQ beta glycoprotein antibody, MHC DQ beta antibody, MHC HLA DQ alpha antibody
|Database links|| |
|Protein function|| |
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
|Protein sequence and domain|| |
Belongs to the MHC class II family. ; Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
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St John’s Laboratory Ltd.
|Product type|| |
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