Rabbit Polyclonal Anti-IFN-alpha/betaRalpha antibody (STJ98705)

$99.00$319.00

Reactivity: Human
Applications: IHC-P, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-IFN-alpha/betaRalpha antibody (STJ98705)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC-P, ELISA

Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|Alpha type antiviral protein antibody|AVP antibody|Beta type antiviral protein antibody|CRF2-1 antibody|Cytokine receptor class-II member 1 antibody|Cytokine receptor family 2 member 1 antibody|IFN alpha REC antibody|IFN alpha receptor antibody|IFN alpha/beta Receptor alpha antibody|IFN beta receptor antibody|IFN-alpha/beta receptor 1 antibody|IFN-R-1 antibody|IFNAR antibody|Ifnar1 antibody|IFNBR antibody|IFRC antibody|INAR1_HUMAN antibody|Interferon (alpha beta and omega) receptor 1 antibody|Interferon alpha/beta receptor 1 antibody|Interferon alpha/beta receptor alpha chain antibody|Interferon beta receptor 1 antibody|Type I interferon receptor 1 antibody|Anti-IFNAR1 antibody [EP899Y] (ab45172)
SCBT cat No: sc-7391|sc-845|sc-704|sc-271105|

Name

Anti-IFN-alpha/betaRalpha antibody

Catalogue No.

STJ98705

Reactivity

Human

Specificity

Anti-IFN-alpha/betaRalpha antibody detects endogenous IFN-alpha/betaRalpha.

Immunogen

Synthetic peptide from human protein at AA range: 300-350.

Host

Rabbit

Applications

IHC-P, ELISA

Recommended dilution

IHC-P 1:50-300; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-IFN-alpha/betaRalpha antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-IFN-alpha/betaRalpha antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Alpha type antiviral protein antibody, AVP antibody, Beta type antiviral protein antibody, CRF2-1 antibody, Cytokine receptor class-II member 1 antibody, Cytokine receptor family 2 member 1 antibody, IFN alpha REC antibody, IFN alpha receptor antibody, IFN alpha/beta Receptor alpha antibody, IFN beta receptor antibody, IFN-alpha/beta receptor 1 antibody, IFN-R-1 antibody, IFNAR antibody, Ifnar1 antibody, IFNBR antibody, IFRC antibody, INAR1_HUMAN antibody, Interferon (alpha beta and omega) receptor 1 antibody, Interferon alpha/beta receptor 1 antibody, Interferon alpha/beta receptor alpha chain antibody, Interferon beta receptor 1 antibody, Type I interferon receptor 1 antibody

Database links

UniProt/Swiss-Prot:P17181

Protein function

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). .

Protein tissue specificity

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. .

Protein sequence and domain

Belongs to the type II cytokine receptor family. ; Contains 4 fibronectin type-III domains.

Protein post-translational modifications

Ubiquitinated, leading to its internalization and degradation (PubMed:14532120, PubMed:15337770). Polyubiquitinated via ‘Lys-48’-linked and ‘Lys-63’-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation (PubMed:18056411). The ‘Lys-63’-linked ubiquitin chains are cleaved off by the BRISC complex (PubMed:24075985). .; Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination (PubMed:14532120, PubMed:15337770, PubMed:24075985). Phosphorylated on tyrosine residues by TYK2 tyrosine kinase (PubMed:7526154). Phosphorylated on tyrosine residues in response to interferon (PubMed:10049744). .; Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2. .

Protein cellular localization

Isoform 1: Cell membrane ; Single-pass type I membrane protein . Late endosome . Lysosome . Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes. .

Research area

All research areas>Membrane Receptors>Interferon Receptor
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize Anti-IFN-alpha/betaRalpha antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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