Rabbit Polyclonal Anti-IL-12B p40 antibody (STJ98797)

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Reactivity: Human
Applications: WB, IHC-P, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-IL-12B p40 antibody (STJ98797)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC-P, ELISA

Recommended dilution: WB 1:500-2000; IHC-P 1:50-300; ELISA 1:5000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

|IL12A antibody| IL12B antibody|CLMF p35 antibody|CLMF p40 antibody|Cytotoxic lymphocyte maturation factor 35 kDa subunit antibody|Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody|Interleukin 12 alpha chain antibody|Interleukin-12 beta chain antibody|NK cell stimulatory factor chain 1 antibody|NK cell stimulatory factor chain 2 antibody|NKSF1 antibody|NKSF2 antibody|Anti-IL12 p70 antibody [QS-12p70] (ab25036)
SCBT cat No: sc-53348|sc-53349|sc-57258|sc-1282|sc-365389|sc-374651|sc-7926|

Name

Anti-IL-12B p40 antibody

Catalogue No.

STJ98797

Reactivity

Human

Specificity

Anti-IL-12B p40 antibody detects endogenous IL-12B p40.

Immunogen

Synthetic peptide from human protein at AA range: 241-290.

Host

Rabbit

Applications

WB, IHC-P, ELISA

Recommended dilution

WB 1:500-2000; IHC-P 1:50-300; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

40kDa

Formulation

Anti-IL-12B p40 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-IL-12B p40 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

IL12A antibody, IL12B antibody, CLMF p35 antibody, CLMF p40 antibody, Cytotoxic lymphocyte maturation factor 35 kDa subunit antibody, Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody, Interleukin 12 alpha chain antibody, Interleukin-12 beta chain antibody, NK cell stimulatory factor chain 1 antibody, NK cell stimulatory factor chain 2 antibody, NKSF1 antibody, NKSF2 antibody

Database links

UniProt/Swiss-Prot:P29460

Protein function

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. .; Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. .

Involvement in disease

Immunodeficiency 29 (IMD29) [MIM:614890]: A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD29 is characterized by undetectable IL12B secretion from leukocytes. Affected individuals generally present with BCG disease after vaccination in childhood, and at least half also have Salmonella infection. Disease phenotype is relatively mild, and patients have a good prognosis. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Psoriasis 11 (PSORS11) [MIM:612599]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the type I cytokine receptor family. Type 3 subfamily. ; Contains 1 fibronectin type-III domain. ; Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Protein post-translational modifications

Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.

Protein cellular localization

Secreted.

Note

AntibodyPlus can customize Anti-IL-12B p40 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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