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Rabbit Polyclonal Anti-IL-1F7 antibody (STJ98774)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-IL-1F7 antibody.
Check alternative names for the antibodyExpand
|FIL1 antibody|Interleukin 1 superfamily z antibody|Interleukin-23 antibody|Anti-IL37 antibody (ab57187)
SCBT cat No: sc-517072|sc-168152|sc-168153|
|Catalogue No.|| |
Anti-IL-1F7 antibody detects endogenous IL-1F7.
Synthetic peptide from human protein at AA range: 101-150.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-IL-1F7 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-IL-1F7 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
FIL1 antibody, Interleukin 1 superfamily z antibody, Interleukin-23 antibody
|Database links|| |
|Protein function|| |
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. .
|Protein tissue specificity|| |
In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. .
|Protein sequence and domain|| |
Belongs to the IL-1 family.
|Protein post-translational modifications|| |
Proteolytically converted to the mature form by CASP1.
|Protein cellular localization|| |
Cytoplasm, cytosol . Nucleus . Secreted . Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730).
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Membrane-Receptors/">Membrane Receptors</a>><a href="http://antibodyplus.com/product-tag/IL-1F/">IL-1F</a><br><a href="http://antibodyplus.com/product-tag/Membrane-Receptors/"> (View all antibody categories related to Membrane Receptors)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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