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Rabbit Polyclonal Anti-Integrin beta7 antibody (STJ99322)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Integrin beta7 antibody.
Check alternative names for the antibodyExpand
|Gut homing receptor beta subunit antibody|Integrin beta 7 subunit antibody|Integrin beta-7 antibody|Integrin beta-P antibody|Integrin, beta 7 antibody|ITB7 antibody|ITB7_HUMAN antibody|Itgb7 antibody|Ly69 antibody|M290 IEL antigen antibody|Anti-Integrin beta 7 antibody (Biotin) [FIB504] SCBT cat No: sc-6637|sc-23919|
Anti-Integrin beta7 antibody
|Catalogue No.|| |
Anti-Integrin beta7 antibody detects endogenous levels of Integrin beta7.
Synthesized peptide derived from human Integrin beta7. at AA range: 671-720.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Integrin beta7 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Integrin beta7 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Gut homing receptor beta subunit antibody, Integrin beta 7 subunit antibody, Integrin beta-7 antibody, Integrin beta-P antibody, Integrin, beta 7 antibody, ITB7 antibody, ITB7_HUMAN antibody, Itgb7 antibody, Ly69 antibody, M290 IEL antigen antibody
|Database links|| |
|Protein function|| |
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
|Protein tissue specificity|| |
Expressed in a variety of leukocyte lines.
|Protein sequence and domain|| |
Belongs to the integrin beta chain family. ; Contains 1 VWFA domain. Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
|Protein cellular localization|| |
Membrane; Single-pass type I membrane protein.
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St John’s Laboratory Ltd.
|Product type|| |
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