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Rabbit Polyclonal Anti-JNK2 antibody (STJ98872)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|c Jun kinase 2 antibody|C Jun N terminal kinase 2 antibody|c-Jun N-terminal kinase 2 antibody|JNK 55 antibody|JNK-55 antibody|JNK2 alpha antibody|JNK2 antibody|JNK2 beta antibody|JNK2A antibody|JNK2alpha antibody|JNK2B antibody|JNK2BETA antibody|Jun kinase antibody|MAP kinase 9 antibody|MAPK 9 antibody|Mapk9 antibody|Mitogen activated protein kinase 9 antibody|Mitogen-activated protein kinase 9 antibody|MK09_HUMAN antibody|P54a antibody|p54aSAPK antibody|PRKM9 antibody|Protein kinase, mitogen-activated, 9 antibody|SAPK alpha antibody|SAPK antibody|SAPK1a antibody|Stress activated protein kinase 1a antibody|Stress-activated protein kinase JNK2 antibody|Anti-JNK2 antibody [EP1595Y] (ab76125)
SCBT cat No: sc-7345|sc-1648|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-JNK2 antibody detects endogenous JNK2 protein.
Recombinant Protein of JNK2.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-JNK2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-JNK2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
c Jun kinase 2 antibody, C Jun N terminal kinase 2 antibody, c-Jun N-terminal kinase 2 antibody, JNK 55 antibody, JNK-55 antibody, JNK2 alpha antibody, JNK2 antibody, JNK2 beta antibody, JNK2A antibody, JNK2alpha antibody, JNK2B antibody, JNK2BETA antibody, Jun kinase antibody, MAP kinase 9 antibody, MAPK 9 antibody, Mapk9 antibody, Mitogen activated protein kinase 9 antibody, Mitogen-activated protein kinase 9 antibody, MK09_HUMAN antibody, P54a antibody, p54aSAPK antibody, PRKM9 antibody, Protein kinase, mitogen-activated, 9 antibody, SAPK alpha antibody, SAPK antibody, SAPK1a antibody, Stress activated protein kinase 1a antibody, Stress-activated protein kinase JNK2 antibody
|Database links|| |
|Protein function|| |
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). .; MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. ; Contains 1 protein kinase domain. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
|Protein post-translational modifications|| |
Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro. .
|Protein cellular localization|| |
Cytoplasm . Nucleus .
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/JNK/">JNK</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"> (View all antibody categories related to Kinases and Phosphatases)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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