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Rabbit Polyclonal Anti-JNK3 antibody (STJ98873)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|c Jun kinase 3 antibody|c-Jun N-terminal kinase 3 antibody|cJun N terminal kinase 3 antibody|FLJ12099 antibody|FLJ33785 antibody|JNK3 alpha protein kinase antibody|JNK3 antibody|JNK3A antibody|MAP kinase 10 antibody|MAP kinase antibody|MAP kinase p49 3F12 antibody|MAPK 10 antibody|Mapk10 antibody|MGC50974 antibody|mitogen activated protein kinase 10 antibody|Mitogen-activated protein kinase 10 antibody|MK10_HUMAN antibody|p493F12 antibody|p54bSAPK antibody|PRKM10 antibody|protein kinase mitogen activated 10 antibody|SAPK1b antibody|Stress activated protein kinase 1b antibody|stress activated protein kinase beta antibody|Stress activated protein kinase JNK3 antibody|Stress-activated protein kinase JNK3 antibody|Anti-JNK3 antibody [EPR5493(2)] (ab126591)
SCBT cat No: sc-130075|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-JNK3 antibody detects endogenous JNK3 protein.
Recombinant Protein of JNK3.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-JNK3 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-JNK3 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
c Jun kinase 3 antibody, c-Jun N-terminal kinase 3 antibody, cJun N terminal kinase 3 antibody, FLJ12099 antibody, FLJ33785 antibody, JNK3 alpha protein kinase antibody, JNK3 antibody, JNK3A antibody, MAP kinase 10 antibody, MAP kinase antibody, MAP kinase p49 3F12 antibody, MAPK 10 antibody, Mapk10 antibody, MGC50974 antibody, mitogen activated protein kinase 10 antibody, Mitogen-activated protein kinase 10 antibody, MK10_HUMAN antibody, p493F12 antibody, p54bSAPK antibody, PRKM10 antibody, protein kinase mitogen activated 10 antibody, SAPK1b antibody, Stress activated protein kinase 1b antibody, stress activated protein kinase beta antibody, Stress activated protein kinase JNK3 antibody, Stress-activated protein kinase JNK3 antibody
|Database links|| |
|Protein function|| |
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). .
|Protein tissue specificity|| |
Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
|Involvement in disease|| |
Note=A chromosomal aberration involving MAPK10 has been found in a single patient with pharmacoresistant epileptic encephalopathy. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. ; Contains 1 protein kinase domain. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
|Protein post-translational modifications|| |
Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro. .; Palmitoylation regulates subcellular location and axonal development. .
|Protein cellular localization|| |
Cytoplasm . Membrane ; Lipid-anchor . Nucleus . Mitochondrion . Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). .
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St John’s Laboratory Ltd.
|Product type|| |
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