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Rabbit Polyclonal Anti-MAP LC3beta antibody (STJ98680)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-MAP LC3beta antibody.
Check alternative names for the antibodyExpand
SCBT cat No:
Anti-MAP LC3beta antibody
|Catalogue No.|| |
Human, Mouse, Rat
Anti-MAP LC3beta antibody detects endogenous MAP LC3beta.
Synthetic peptide from human protein at AA range: 1-50.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:5000-20000
|Molecular weight|| |
Anti-MAP LC3beta antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-MAP LC3beta antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Database links|| |
|Protein function|| |
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. .
|Protein tissue specificity|| |
Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver. .
|Protein sequence and domain|| |
Belongs to the ATG8 family.
|Protein post-translational modifications|| |
The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094). .; The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.; Phosphorylation at Thr-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE) (By similarity). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity. .
|Protein cellular localization|| |
Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome . Note=LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). .
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St John’s Laboratory Ltd.
|Product type|| |
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