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Rabbit Polyclonal Anti-NAIP antibody (STJ99015)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|Baculoviral IAP repeat containing 1 antibody|Baculoviral IAP repeat-containing protein 1 antibody|BIRC 1 antibody|BIRC1 antibody|BIRC1_HUMAN antibody|Birc1a antibody|FLJ42520 antibody|NAIP antibody|Naip1 antibody|Neuronal apoptosis inhibitory protein antibody|NLR family apoptosis inhibitory protein antibody|NLR family BIR domain containing 1 antibody|NLRB 1 antibody|NLRB1 antibody|Nucleotide binding oligomerization domain leucine rich repeat and BIR domain containing 1 antibody|Psi neuronal apoptosis inhibitory protein antibody|psiNAIP antibody|Similar to occludin antibody|Anti-NAIP antibody (ab25968)
SCBT cat No: sc-11059|sc-11064|
|Catalogue No.|| |
Anti-NAIP antibody detects endogenous NAIP .
Synthetic peptide from human protein at AA range: 1191-1240.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
Anti-NAIP antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-NAIP antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Baculoviral IAP repeat containing 1 antibody, Baculoviral IAP repeat-containing protein 1 antibody, BIRC 1 antibody, BIRC1 antibody, BIRC1_HUMAN antibody, Birc1a antibody, FLJ42520 antibody, NAIP antibody, Naip1 antibody, Neuronal apoptosis inhibitory protein antibody, NLR family apoptosis inhibitory protein antibody, NLR family BIR domain containing 1 antibody, NLRB 1 antibody, NLRB1 antibody, Nucleotide binding oligomerization domain leucine rich repeat and BIR domain containing 1 antibody, Psi neuronal apoptosis inhibitory protein antibody, psiNAIP antibody, Similar to occludin antibody
|Database links|| |
|Protein function|| |
Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at ‘Asp-315’ and decreasing the rate of auto proteolysis at ‘Asp-330’. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.; Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.
|Protein tissue specificity|| |
Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.
|Protein sequence and domain|| |
Contains 3 BIR repeats. ; Contains 1 NACHT domain. Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1.
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St John’s Laboratory Ltd.
|Product type|| |
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