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Rabbit Polyclonal Anti-NCAM-L1 antibody (STJ98757)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-NCAM-L1 antibody.
Check alternative names for the antibodyExpand
|Antigen identified by monoclonal antibody R1 antibody|CAML1 antibody|CD171 antibody|CD171 antigen antibody|HSAS antibody|HSAS1 antibody|Hyd antibody|L1 antibody|L1 cell adhesion molecule antibody|L1-NCAM antibody|L1cam antibody|L1CAM_HUMAN antibody|MASA antibody|MIC5 antibody|N CAML1 antibody|N-CAM-L1 antibody|NCAM-L1 antibody|NCAML1 antibody|Nerve-growth factor-inducible large external glycoprotein antibody|Neural cell adhesion molecule L1 antibody|NILE antibody|OTTHUMP00000025992 antibody|S10 antibody|SPG1 antibody|Anti-L1CAM antibody [2C2] (ab24345)
SCBT cat No: sc-71653|sc-33686|sc-59868|sc-514360|sc-1508|sc-374046|sc-15326|sc-8305|sc-31034|sc-31032|sc-53386|sc-53387|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-NCAM-L1 antibody detects endogenous NCAM-L1.
Synthetic peptide from human protein at AA range: 151-200.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-NCAM-L1 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-NCAM-L1 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Antigen identified by monoclonal antibody R1 antibody, CAML1 antibody, CD171 antibody, CD171 antigen antibody, HSAS antibody, HSAS1 antibody, Hyd antibody, L1 antibody, L1 cell adhesion molecule antibody, L1-NCAM antibody, L1cam antibody, L1CAM_HUMAN antibody, MASA antibody, MIC5 antibody, N CAML1 antibody, N-CAM-L1 antibody, NCAM-L1 antibody, NCAML1 antibody, Nerve-growth factor-inducible large external glycoprotein antibody, Neural cell adhesion molecule L1 antibody, NILE antibody, OTTHUMP00000025992 antibody, S10 antibody, SPG1 antibody
|Database links|| |
|Protein function|| |
Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.
|Involvement in disease|| |
Hydrocephalus due to stenosis of the aqueduct of Sylvius (HSAS) [MIM:307000]: Hydrocephalus is a condition in which abnormal accumulation of cerebrospinal fluid in the brain causes increased intracranial pressure inside the skull. This is usually due to blockage of cerebrospinal fluid outflow in the brain ventricles or in the subarachnoid space at the base of the brain. In children is typically characterized by enlargement of the head, prominence of the forehead, brain atrophy, mental deterioration, and convulsions. In adults the syndrome includes incontinence, imbalance, and dementia. HSAS is characterized by mental retardation and enlarged brain ventricles. . Note=The disease is caused by mutations affecting the gene represented in this entry. L1CAM mutations have also been found in few patients affected by hydrocephalus with Hirschsprung disease, suggesting a role of this gene acting either in a direct or indirect way in the pathogenesis of Hirschsprung disease (PubMed:22344793). .; Mental retardation, aphasia, shuffling gait, and adducted thumbs syndrome (MASA) [MIM:303350]: An X-linked recessive syndrome with a highly variable clinical spectrum. Main clinical features include spasticity and hyperreflexia of lower limbs, shuffling gait, mental retardation, aphasia and adducted thumbs. The features of spasticity have been referred to as complicated spastic paraplegia type 1 (SPG1). Some patients manifest corpus callosum hypoplasia and hydrocephalus. Inter- and intrafamilial variability is very wide, such that patients with hydrocephalus, MASA, SPG1, and agenesis of corpus callosum can be present within the same family. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Spastic paraplegia 1, X-linked (SPG1) [MIM:303350]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=Defects in L1CAM may contribute to Hirschsprung disease by modifying the effects of Hirschsprung disease-associated genes to cause intestinal aganglionosis. .; Agenesis of the corpus callosum, X-linked, partial (ACCPX) [MIM:304100]: A syndrome characterized by partial corpus callosum agenesis, hypoplasia of inferior vermis and cerebellum, mental retardation, seizures and spasticity. Other features include microcephaly, unusual facies, and Hirschsprung disease in some patients. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. ; Contains 5 fibronectin type-III domains. ; Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
|Protein cellular localization|| |
Cell membrane ; Single-pass type I membrane protein . Cell projection, growth cone . Note=Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons. .
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St John’s Laboratory Ltd.
|Product type|| |
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