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Rabbit Polyclonal Anti-NFATc2 antibody (STJ98986)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-NFATc2 antibody.
Check alternative names for the antibodyExpand
|AI607462 antibody|cytoplasmic 2 antibody|KIAA0611 antibody|NF ATc2 antibody|NF ATp antibody|NF-ATc2 antibody|NF-ATp antibody|NFAC2_HUMAN antibody|NFAT 1 antibody|NFAT pre existing subunit antibody|NFAT pre-existing subunit antibody|NFAT transcription complex, preexisting component antibody|NFAT1 antibody|NFAT1-D antibody|NFATc2 antibody|NFATp antibody|Nuclear factor of activated T cells cytoplasmic 2 antibody|Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2 antibody|Nuclear factor of activated T cells pre-existing component antibody|Nuclear factor of activated T cells, preexisting component antibody|Nuclear factor of activated T-cells antibody|Preexisting nuclear factor of activated T cells 2 antibody|T cell transcription factor NFAT 1 antibody|T-cell transcription factor NFAT1 antibody|Anti-NFAT1 antibody [25A10.D6.D2] – ChIP Grade (ab2722)
SCBT cat No: sc-1151|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-NFATc2 antibody detects endogenous NFATc2 .
Synthetic peptide from human protein at AA range: 640-700.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
Anti-NFATc2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-NFATc2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
AI607462 antibody, cytoplasmic 2 antibody, KIAA0611 antibody, NF ATc2 antibody, NF ATp antibody, NF-ATc2 antibody, NF-ATp antibody, NFAC2_HUMAN antibody, NFAT 1 antibody, NFAT pre existing subunit antibody, NFAT pre-existing subunit antibody, NFAT transcription complex, preexisting component antibody, NFAT1 antibody, NFAT1-D antibody, NFATc2 antibody, NFATp antibody, Nuclear factor of activated T cells cytoplasmic 2 antibody, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2 antibody, Nuclear factor of activated T cells pre-existing component antibody, Nuclear factor of activated T cells, preexisting component antibody, Nuclear factor of activated T-cells antibody, Preexisting nuclear factor of activated T cells 2 antibody, T cell transcription factor NFAT 1 antibody, T-cell transcription factor NFAT1 antibody
|Database links|| |
|Protein function|| |
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. .
|Protein tissue specificity|| |
Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid. .
|Protein sequence and domain|| |
Contains 1 RHD (Rel-like) domain. the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. ; Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
|Protein post-translational modifications|| |
In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full transcriptional activity. .; Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome. .
|Protein cellular localization|| |
Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
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St John’s Laboratory Ltd.
|Product type|| |
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