Rabbit Polyclonal Anti-NFATc2 antibody (STJ98986)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Polyclonal Anti-NFATc2 antibody (STJ98986)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Anti-NFATc2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

|AI607462 antibody|cytoplasmic 2 antibody|KIAA0611 antibody|NF ATc2 antibody|NF ATp antibody|NF-ATc2 antibody|NF-ATp antibody|NFAC2_HUMAN antibody|NFAT 1 antibody|NFAT pre existing subunit antibody|NFAT pre-existing subunit antibody|NFAT transcription complex, preexisting component antibody|NFAT1 antibody|NFAT1-D antibody|NFATc2 antibody|NFATp antibody|Nuclear factor of activated T cells cytoplasmic 2 antibody|Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2 antibody|Nuclear factor of activated T cells pre-existing component antibody|Nuclear factor of activated T cells, preexisting component antibody|Nuclear factor of activated T-cells antibody|Preexisting nuclear factor of activated T cells 2 antibody|T cell transcription factor NFAT 1 antibody|T-cell transcription factor NFAT1 antibody|Anti-NFAT1 antibody [25A10.D6.D2] – ChIP Grade (ab2722)
SCBT cat No: sc-1151|

Name

Anti-NFATc2 antibody

Catalogue No.

STJ98986

Reactivity

Human, Mouse, Rat

Specificity

Anti-NFATc2 antibody detects endogenous NFATc2 .

Immunogen

Synthetic peptide from human protein at AA range: 640-700.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-NFATc2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-NFATc2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

AI607462 antibody, cytoplasmic 2 antibody, KIAA0611 antibody, NF ATc2 antibody, NF ATp antibody, NF-ATc2 antibody, NF-ATp antibody, NFAC2_HUMAN antibody, NFAT 1 antibody, NFAT pre existing subunit antibody, NFAT pre-existing subunit antibody, NFAT transcription complex, preexisting component antibody, NFAT1 antibody, NFAT1-D antibody, NFATc2 antibody, NFATp antibody, Nuclear factor of activated T cells cytoplasmic 2 antibody, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2 antibody, Nuclear factor of activated T cells pre-existing component antibody, Nuclear factor of activated T cells, preexisting component antibody, Nuclear factor of activated T-cells antibody, Preexisting nuclear factor of activated T cells 2 antibody, T cell transcription factor NFAT 1 antibody, T-cell transcription factor NFAT1 antibody

Database links

UniProt/Swiss-Prot:Q13469

Protein function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. .

Protein tissue specificity

Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid. .

Protein sequence and domain

Contains 1 RHD (Rel-like) domain. the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. ; Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.

Protein post-translational modifications

In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full transcriptional activity. .; Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome. .

Protein cellular localization

Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Research area

All research areas>Transcription Regulators>NFAT
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Anti-NFATc2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!