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Rabbit Polyclonal Anti-Nrf2 antibody (STJ98927)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Nrf2 antibody.
Check alternative names for the antibodyExpand
|erythroid derived 2 antibody|Nuclear factor erythroid derived 2 like 2 antibody|Phospho anti-Nrf2 (S40) antibody [EP1809Y] (ab76026)
SCBT cat No: sc-81342|sc-365949|sc-722|sc-13032|sc-30915|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-Nrf2 antibody detects endogenous Nrf2 protein.
Recombinant Protein of Nrf2.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Nrf2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Nrf2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
erythroid derived 2 antibody, Nuclear factor erythroid derived 2 like 2 antibody
|Database links|| |
|Protein function|| |
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. .
|Protein tissue specificity|| |
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
|Protein sequence and domain|| |
Belongs to the bZIP family. CNC subfamily. ; Contains 1 bZIP (basic-leucine zipper) domain. Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.
|Protein post-translational modifications|| |
Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus. .; Acetylation at Lys-596 and Lys-599 increases nuclear localization whereas deacetylation by SIRT1 enhances cytoplasmic presence. .; Ubiquitinated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and subject to proteasomal degradation. Ubiquitination is inhibited by sulforaphane. .
|Protein cellular localization|| |
Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
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St John’s Laboratory Ltd.
|Product type|| |
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