Rabbit Polyclonal Anti-Nrf2 antibody (STJ98927)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-Nrf2 antibody (STJ98927)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|erythroid derived 2 antibody|Nuclear factor erythroid derived 2 like 2 antibody|Phospho anti-Nrf2 (S40) antibody [EP1809Y] (ab76026)
SCBT cat No: sc-81342|sc-365949|sc-722|sc-13032|sc-30915|

Name

Anti-Nrf2 antibody

Catalogue No.

STJ98927

Reactivity

Human, Mouse, Rat

Specificity

Anti-Nrf2 antibody detects endogenous Nrf2 protein.

Immunogen

Recombinant Protein of Nrf2.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

75-100kDa

Formulation

Anti-Nrf2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Nrf2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

erythroid derived 2 antibody, Nuclear factor erythroid derived 2 like 2 antibody

Database links

UniProt/Swiss-Prot:Q16236

Protein function

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. .

Protein tissue specificity

Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

Protein sequence and domain

Belongs to the bZIP family. CNC subfamily. ; Contains 1 bZIP (basic-leucine zipper) domain. Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.

Protein post-translational modifications

Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus. .; Acetylation at Lys-596 and Lys-599 increases nuclear localization whereas deacetylation by SIRT1 enhances cytoplasmic presence. .; Ubiquitinated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and subject to proteasomal degradation. Ubiquitination is inhibited by sulforaphane. .

Protein cellular localization

Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.

Research area

All research areas>Transcription Regulators>Nuclear Factor Erythroid 2-Related Factor
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Anti-Nrf2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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