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Rabbit Polyclonal Anti-p53 (Acetyl K120) antibody (STJ98844)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:5000-20014
Recommended protocols: check protocols
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SCBT cat No:
Anti-p53 (Acetyl K120) antibody
|Catalogue No.|| |
Anti-p53 (Acetyl K120) antibody detects endogenous levels of GLI-1.
Synthesized peptide derived from Human GLI-1 at AA range: 460-490.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:5000-20014
Anti-p53 (Acetyl K120) antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-p53 (Acetyl K120) antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Database links|| |
|Protein function|| |
Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5′-GACCACCCA-3′ (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). .; Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. .
|Protein tissue specificity|| |
Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761). .
|Protein sequence and domain|| |
Belongs to the GLI C2H2-type zinc-finger protein family. ; Contains 5 C2H2-type zinc fingers.
|Protein post-translational modifications|| |
Phosphorylated in vitro by ULK3. .; Acetylation at Lys-518 down-regulates transcriptional activity. Deacetylated by HDAC1. .
|Protein cellular localization|| |
Cytoplasm . Nucleus . Note=Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441). .; Isoform 2: Cytoplasm . Nucleus .
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St John’s Laboratory Ltd.
|Product type|| |
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