Rabbit Polyclonal Anti-PARP-1 (Acetyl K521) antibody (STJ98846)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-PARP-1 (Acetyl K521) antibody (STJ98846)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:5000-20016

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|DmelCG6376 antibody|Dmel_CG6376 antibody|drosE2F1 antibody|E(Sev-CycE)3A antibody|E(var)3-93E antibody|E2-promoter binding facto antibody|E2F 1 antibody|E2F transcription factor 1 antibody|E2F-1 antibody|E2f-PA antibody|E2f-PB antibody|E2f-PC antibody|E2F1 antibody|E2f1 E2F transcription factor 1 antibody|E2F1_HUMAN antibody|Evar(3)164 antibody|KIAA4009 antibody|l(3)07172 antibody|l(3)j3B1 antibody|l(3)j3C2 antibody|l(3)rM729 antibody|mKIAA4009 antibody|OTTHUMP00000030661 antibody|PBR3 antibody|PRB binding protein E2F 1 antibody|PRB-binding protein E2F-1 antibody|RBAP 1 antibody|RBAP-1 antibody|RBAP1 antibody|RBBP-3 antibody|RBBP3 antibody|RBP 3 antibody|RBP3 antibody|Retinoblastoma-associated protein 1 antibody|Retinoblastoma-binding protein 3 antibody|Transcription factor E2F1 antibody|Anti-E2F1 antibody [EPR3818(3)] (ab179445)
SCBT cat No: sc-193|sc-137059|sc-137110|sc-137060|sc-22820|sc-56661|sc-56662|sc-251|sc-515402|

Name

Anti-PARP-1 (Acetyl K521) antibody

Catalogue No.

STJ98846

Reactivity

Human, Mouse, Rat

Specificity

Anti-PARP-1 (Acetyl K521) antibody detects endogenous levels of E2F-1.

Immunogen

Synthesized peptide derived from Human E2F-1 at AA range: 100-140.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:5000-20016

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-PARP-1 (Acetyl K521) antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-PARP-1 (Acetyl K521) antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

DmelCG6376 antibody, Dmel_CG6376 antibody, drosE2F1 antibody, E(Sev-CycE)3A antibody, E(var)3-93E antibody, E2-promoter binding facto antibody, E2F 1 antibody, E2F transcription factor 1 antibody, E2F-1 antibody, E2f-PA antibody, E2f-PB antibody, E2f-PC antibody, E2F1 antibody, E2f1 E2F transcription factor 1 antibody, E2F1_HUMAN antibody, Evar(3)164 antibody, KIAA4009 antibody, l(3)07172 antibody, l(3)j3B1 antibody, l(3)j3C2 antibody, l(3)rM729 antibody, mKIAA4009 antibody, OTTHUMP00000030661 antibody, PBR3 antibody, PRB binding protein E2F 1 antibody, PRB-binding protein E2F-1 antibody, RBAP 1 antibody, RBAP-1 antibody, RBAP1 antibody, RBBP-3 antibody, RBBP3 antibody, RBP 3 antibody, RBP3 antibody, Retinoblastoma-associated protein 1 antibody, Retinoblastoma-binding protein 3 antibody, Transcription factor E2F1 antibody

Database links

UniProt/Swiss-Prot:Q01094

Protein function

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5′-TTTC[CG]CGC-3′ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). .

Protein sequence and domain

Belongs to the E2F/DP family.

Protein post-translational modifications

Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis. .; Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by P/CAF/KAT2B. .

Protein cellular localization

Nucleus.

Research area

All research areas>Transcription Regulators>E2F
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Anti-PARP-1 (Acetyl K521) antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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