Rabbit Polyclonal Anti-PI 3-Kinase p85beta antibody (STJ98987)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-PI 3-Kinase p85beta antibody (STJ98987)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|p85 antibody|p85 beta antibody|P85B antibody|P85B_HUMAN antibody|Phosphatidylinositol 3 kinase antibody|Phosphatidylinositol 3 kinase regulatory beta subunit antibody|Phosphatidylinositol 3 kinase regulatory subunit beta antibody|Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2 antibody|Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta) antibody|Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta antibody|Phosphatidylinositol 3-kinase regulatory subunit beta antibody|Phosphoinositide 3 kinase regulatory subunit 2 (beta) antibody|Phosphoinositide 3 kinase regulatory subunit 2 antibody|Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta) antibody|Phosphoinositide 3 kinase regulatory subunit polypeptide 2 antibody|Phosphoinositide 3 kinase, regulatory subunit 2 (beta) antibody|Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta) antibody|PI3 kinase p85 beta subunit antibody|PI3 kinase p85 subunit beta antibody|PI3-kinase regulatory subunit beta antibody|PI3-kinase subunit p85-beta antibody|PI3K antibody|PI3K regulatory subunit beta antibody|PIK3R 2 antibody|PIK3R2 antibody|PtdIns 3 kinase p85 beta antibody|PtdIns-3-kinase regulatory subunit beta antibody|PtdIns-3-kinase regulatory subunit p85-beta antibody|Anti-PI 3 Kinase p85 beta antibody [EPR18416] (ab180967)
SCBT cat No: sc-374534|sc-292114|sc-131324|sc-131325|

Name

Anti-PI 3-Kinase p85beta antibody

Catalogue No.

STJ98987

Reactivity

Human, Mouse, Rat

Specificity

Anti-PI 3-Kinase p85beta antibody detects endogenous PI 3-Kinase p85beta .

Immunogen

Synthetic peptide from human protein at AA range: 1-60.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-PI 3-Kinase p85beta antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-PI 3-Kinase p85beta antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

p85 antibody, p85 beta antibody, P85B antibody, P85B_HUMAN antibody, Phosphatidylinositol 3 kinase antibody, Phosphatidylinositol 3 kinase regulatory beta subunit antibody, Phosphatidylinositol 3 kinase regulatory subunit beta antibody, Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2 antibody, Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta) antibody, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta antibody, Phosphatidylinositol 3-kinase regulatory subunit beta antibody, Phosphoinositide 3 kinase regulatory subunit 2 (beta) antibody, Phosphoinositide 3 kinase regulatory subunit 2 antibody, Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta) antibody, Phosphoinositide 3 kinase regulatory subunit polypeptide 2 antibody, Phosphoinositide 3 kinase, regulatory subunit 2 (beta) antibody, Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta) antibody, PI3 kinase p85 beta subunit antibody, PI3 kinase p85 subunit beta antibody, PI3-kinase regulatory subunit beta antibody, PI3-kinase subunit p85-beta antibody, PI3K antibody, PI3K regulatory subunit beta antibody, PIK3R 2 antibody, PIK3R2 antibody, PtdIns 3 kinase p85 beta antibody, PtdIns-3-kinase regulatory subunit beta antibody, PtdIns-3-kinase regulatory subunit p85-beta antibody

Database links

UniProt/Swiss-Prot:O00459

Protein function

Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). .

Involvement in disease

Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1) [MIM:603387]: A syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the PI3K p85 subunit family. ; Contains 1 Rho-GAP domain. ; Contains 2 SH2 domains. ; Contains 1 SH3 domain. The SH2 2 domain is required for interaction with FBXL2 and PTPN13.

Protein post-translational modifications

Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317). .; Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2. .

Research area

All research areas>Kinases and Phosphatases>PI 3-kinase
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Anti-PI 3-Kinase p85beta antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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