Rabbit Polyclonal Anti-PLK2 antibody (STJ98963)

$99.00$319.00

Reactivity: Human, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Polyclonal Anti-PLK2 antibody (STJ98963)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Anti-PLK2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

|hPlk2 antibody|hSNK antibody|PLK-2 antibody|Plk2 antibody|PLK2_HUMAN antibody|Polo like kinase 2 antibody|Polo-like kinase 2 antibody|Serine/threonine protein kinase PLK2 antibody|Serine/threonine protein kinase SNK antibody|Serine/threonine-protein kinase PLK2 antibody|Serine/threonine-protein kinase SNK antibody|Serum Induced Kinase antibody|Serum-inducible kinase antibody|SNK antibody|Anti-PLK2 antibody (ab71311)
SCBT cat No:

Name

Anti-PLK2 antibody

Catalogue No.

STJ98963

Reactivity

Human, Rat

Specificity

Anti-PLK2 antibody detects endogenous PLK2.

Immunogen

Synthetic peptide from human protein at AA range: 377-451.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-PLK2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-PLK2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

hPlk2 antibody, hSNK antibody, PLK-2 antibody, Plk2 antibody, PLK2_HUMAN antibody, Polo like kinase 2 antibody, Polo-like kinase 2 antibody, Serine/threonine protein kinase PLK2 antibody, Serine/threonine protein kinase SNK antibody, Serine/threonine-protein kinase PLK2 antibody, Serine/threonine-protein kinase SNK antibody, Serum Induced Kinase antibody, Serum-inducible kinase antibody, SNK antibody

Database links

UniProt/Swiss-Prot:Q9NYY3

Protein function

Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. .

Protein tissue specificity

Expressed at higher level in the fetal lung, kidney, spleen and heart. .

Protein sequence and domain

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. ; Contains 2 POLO box domains. ; Contains 1 protein kinase domain. The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK2 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them (By similarity).

Protein post-translational modifications

Catalytic activity is enhanced by phosphorylation of Thr-239. .

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, dendrite . Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.

Research area

All research areas>Kinases and Phosphatases>Snk
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Anti-PLK2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!