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Rabbit Polyclonal Anti-RPA14 antibody (STJ98675)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-RPA14 antibody.
Check alternative names for the antibodyExpand
|p14 antibody|REPA 3 antibody|REPA3 antibody|Replication factor A protein 3 antibody|Replication protein A 14 kDa subunit antibody|Replication protein A3 14kD antibody|Replication protein A3 14kDa antibody|Replication protein A3 antibody|RF A antibody|RF A protein 3 antibody|RF-A protein 3 antibody|RFA protein 3 antibody|RFA3_HUMAN antibody|RP A antibody|RP A p14 antibody|RP-A p14 antibody|RPA 14 antibody|RPA 3 antibody|RPA p14 antibody|rpa3 antibody|Anti-HIV1 tat antibody – ChIP Grade (ab43014)
SCBT cat No: sc-30411|sc-271564|sc-46507|
|Catalogue No.|| |
Anti-RPA14 antibody detects endogenous RPA14.
Synthetic peptide from human protein at AA range: 30-80.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:5000-20000
|Molecular weight|| |
Anti-RPA14 antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-RPA14 antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
p14 antibody, REPA 3 antibody, REPA3 antibody, Replication factor A protein 3 antibody, Replication protein A 14 kDa subunit antibody, Replication protein A3 14kD antibody, Replication protein A3 14kDa antibody, Replication protein A3 antibody, RF A antibody, RF A protein 3 antibody, RF-A protein 3 antibody, RFA protein 3 antibody, RFA3_HUMAN antibody, RP A antibody, RP A p14 antibody, RP-A p14 antibody, RPA 14 antibody, RPA 3 antibody, RPA p14 antibody, rpa3 antibody
|Database links|| |
|Protein function|| |
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). .
|Protein cellular localization|| |
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="http://antibodyplus.com/product-tag/Replication-Protein-A/">Replication Protein A</a><br><a href="http://antibodyplus.com/product-tag/Transcription-Regulators/"> (View all antibody categories related to Transcription Regulators)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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