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Rabbit Polyclonal Anti-Sodium Potassium ATPase alpha-1 antibody (Phospho-Tyr260) (STJ98679)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:5000-20000
Recommended protocols: check protocols
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SCBT cat No:
Anti-Sodium Potassium ATPase alpha-1 antibody (Phospho-Tyr260)
|Catalogue No.|| |
Human, Mouse, Rat
Anti-Sodium Potassium ATPase alpha-1 antibody (Phospho-Tyr260) detects endogenous Sodium Potassium ATPase alpha-1 when Phospho occurs at Tyr260).
Synthetic peptide from human protein at AA range: 230-290.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:5000-20000
|Molecular weight|| |
Anti-Sodium Potassium ATPase alpha-1 antibody (Phospho-Tyr260) was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-Sodium Potassium ATPase alpha-1 antibody (Phospho-Tyr260) was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Database links|| |
|Protein function|| |
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
|Protein sequence and domain|| |
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
|Protein post-translational modifications|| |
Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity). .
|Protein cellular localization|| |
Cell membrane ; Multi-pass membrane protein . Melanosome . Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
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St John’s Laboratory Ltd.
|Product type|| |
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