Rabbit Polyclonal Anti-Tenascin-R antibody (STJ98728)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: IHC-P, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-Tenascin-R antibody (STJ98728)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC-P, ELISA

Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

|Janusin antibody|MGC149328 antibody|Restrictin antibody|Tenascin R (restrictin, janusin) antibody|Tenascin-R antibody|TENR_HUMAN antibody|TN-R antibody|Tnr antibody|Anti-TNR antibody (ab198863)
SCBT cat No:

Name

Anti-Tenascin-R antibody

Catalogue No.

STJ98728

Reactivity

Human, Mouse, Rat

Specificity

Anti-Tenascin-R antibody detects endogenous Tenascin-R.

Immunogen

Synthetic peptide from human protein at AA range: 1270-1350.

Host

Rabbit

Applications

IHC-P, ELISA

Recommended dilution

IHC-P 1:50-300; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-Tenascin-R antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-Tenascin-R antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Janusin antibody, MGC149328 antibody, Restrictin antibody, Tenascin R (restrictin, janusin) antibody, Tenascin-R antibody, TENR_HUMAN antibody, TN-R antibody, Tnr antibody

Database links

UniProt/Swiss-Prot:Q92752

Protein function

Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). .

Protein tissue specificity

Brain specific. .

Protein sequence and domain

Belongs to the tenascin family. ; Contains 5 EGF-like domains. ; Contains 1 fibrinogen C-terminal domain. ; Contains 9 fibronectin type-III domains. The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B (By similarity).

Protein post-translational modifications

Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity). O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan. .

Protein cellular localization

Secreted, extracellular space, extracellular matrix.

Note

AntibodyPlus can customize Anti-Tenascin-R antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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