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Rabbit Polyclonal Anti-Tenascin-R antibody (STJ98728)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Tenascin-R antibody.
Check alternative names for the antibodyExpand
|Janusin antibody|MGC149328 antibody|Restrictin antibody|Tenascin R (restrictin, janusin) antibody|Tenascin-R antibody|TENR_HUMAN antibody|TN-R antibody|Tnr antibody|Anti-TNR antibody (ab198863)
SCBT cat No:
|Catalogue No.|| |
Human, Mouse, Rat
Anti-Tenascin-R antibody detects endogenous Tenascin-R.
Synthetic peptide from human protein at AA range: 1270-1350.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-Tenascin-R antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-Tenascin-R antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Janusin antibody, MGC149328 antibody, Restrictin antibody, Tenascin R (restrictin, janusin) antibody, Tenascin-R antibody, TENR_HUMAN antibody, TN-R antibody, Tnr antibody
|Database links|| |
|Protein function|| |
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). .
|Protein tissue specificity|| |
Brain specific. .
|Protein sequence and domain|| |
Belongs to the tenascin family. ; Contains 5 EGF-like domains. ; Contains 1 fibrinogen C-terminal domain. ; Contains 9 fibronectin type-III domains. The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B (By similarity).
|Protein post-translational modifications|| |
Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity). O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan. .
|Protein cellular localization|| |
Secreted, extracellular space, extracellular matrix.
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St John’s Laboratory Ltd.
|Product type|| |
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