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Rabbit Polyclonal Anti-Thioredoxin antibody (STJ98852)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:5000-20022
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Thioredoxin antibody.
Check alternative names for the antibodyExpand
|ADF antibody|ATL derived factor antibody|ATL-derived factor antibody|DKFZp686B1993 antibody|MGC61975 antibody|SASP antibody|Surface associated sulphydryl protein antibody|Surface-associated sulphydryl protein antibody|testicular tissue protein Li 199 antibody|THIO_HUMAN antibody|Thioredoxin antibody|thioredoxin delta 3 antibody|TRDX antibody|TRX 1 antibody|Trx antibody|TRX1 antibody|TXN antibody|TXN delta 3 antibody|TXN protein antibody|zgc:92903 antibody|Anti-Thioredoxin / TRX antibody (ab26320)
SCBT cat No:
|Catalogue No.|| |
Human, Mouse, Rat
Anti-Thioredoxin antibody detects endogenous levels of Thioredoxin.
Synthesized peptide derived from Human Thioredoxin at AA range: 52-101.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:5000-20022
Anti-Thioredoxin antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Thioredoxin antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ADF antibody, ATL derived factor antibody, ATL-derived factor antibody, DKFZp686B1993 antibody, MGC61975 antibody, SASP antibody, Surface associated sulphydryl protein antibody, Surface-associated sulphydryl protein antibody, testicular tissue protein Li 199 antibody, THIO_HUMAN antibody, Thioredoxin antibody, thioredoxin delta 3 antibody, TRDX antibody, TRX 1 antibody, Trx antibody, TRX1 antibody, TXN antibody, TXN delta 3 antibody, TXN protein antibody, zgc:92903 antibody
|Database links|| |
|Protein function|| |
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.; ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
|Protein sequence and domain|| |
Belongs to the thioredoxin family. ; Contains 1 thioredoxin domain.
|Protein post-translational modifications|| |
In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins. .; In case of infection, ubiquitinated by S.typhimurium protein slrP, leading to its degradation. .
|Protein cellular localization|| |
Nucleus . Cytoplasm . Secreted . Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947). .
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Synthesis-and-Degradation/">Synthesis and Degradation</a>><a href="http://antibodyplus.com/product-tag/Trx/">Trx</a><br><a href="http://antibodyplus.com/product-tag/Synthesis-and-Degradation/"> (View all antibody categories related to Synthesis and Degradation)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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