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Rabbit Polyclonal Anti-Thyroglobulin antibody (STJ98806)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Thyroglobulin antibody.
Check alternative names for the antibodyExpand
|AITD 3 antibody|AITD3 antibody|hTG antibody|TDH3 antibody|Tg antibody|TGN antibody|THYG_HUMAN antibody|Thyroglobulin antibody|Anti-Thyroglobulin antibody [EPR9730] (ab156008)
SCBT cat No:
|Catalogue No.|| |
Human, Mouse, Rat
Anti-Thyroglobulin antibody detects endogenous Thyroglobulin.
Synthetic peptide from human protein at AA range: 2511-2560.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-Thyroglobulin antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-Thyroglobulin antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
AITD 3 antibody, AITD3 antibody, hTG antibody, TDH3 antibody, Tg antibody, TGN antibody, THYG_HUMAN antibody, Thyroglobulin antibody
|Database links|| |
|Protein function|| |
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
|Protein tissue specificity|| |
Thyroid gland specific.
|Involvement in disease|| |
Thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]: A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Autoimmune thyroid disease 3 (AITD3) [MIM:608175]: A complex autoimmune disorder comprising two related diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2 differentiation and activate B-cells to produce antibodies against the TSH receptor, which stimulate the thyroid and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the type-B carboxylesterase/lipase family. ; Contains 11 thyroglobulin type-1 domains.
|Protein post-translational modifications|| |
Sulfated tyrosines are desulfated during iodination. .
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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