Rabbit Polyclonal Anti-Thyroglobulin antibody (STJ98806)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: IHC-P, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-Thyroglobulin antibody (STJ98806)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC-P, ELISA

Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|AITD 3 antibody|AITD3 antibody|hTG antibody|TDH3 antibody|Tg antibody|TGN antibody|THYG_HUMAN antibody|Thyroglobulin antibody|Anti-Thyroglobulin antibody [EPR9730] (ab156008)
SCBT cat No:

Name

Anti-Thyroglobulin antibody

Catalogue No.

STJ98806

Reactivity

Human, Mouse, Rat

Specificity

Anti-Thyroglobulin antibody detects endogenous Thyroglobulin.

Immunogen

Synthetic peptide from human protein at AA range: 2511-2560.

Host

Rabbit

Applications

IHC-P, ELISA

Recommended dilution

IHC-P 1:50-300; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-Thyroglobulin antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-Thyroglobulin antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

AITD 3 antibody, AITD3 antibody, hTG antibody, TDH3 antibody, Tg antibody, TGN antibody, THYG_HUMAN antibody, Thyroglobulin antibody

Database links

UniProt/Swiss-Prot:P01266

Protein function

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

Protein tissue specificity

Thyroid gland specific.

Involvement in disease

Thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]: A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Autoimmune thyroid disease 3 (AITD3) [MIM:608175]: A complex autoimmune disorder comprising two related diseases affecting the thyroid: Graves disease and Hashimoto thyroiditis. In both disorders, thyroid-reactive T-cells are formed and infiltrate the thyroid gland. In Graves disease, the majority of the T-cells undergo a Th2 differentiation and activate B-cells to produce antibodies against the TSH receptor, which stimulate the thyroid and cause clinical hyperthyroidism. In contrast, Hashimoto thyroiditis is characterized by Th1 switching of the thyroid-infiltrating T-cells, which induces apoptosis of thyroid follicular cells and clinical hypothyroidism. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the type-B carboxylesterase/lipase family. ; Contains 11 thyroglobulin type-1 domains.

Protein post-translational modifications

Sulfated tyrosines are desulfated during iodination. .

Protein cellular localization

Secreted.

Note

AntibodyPlus can customize Anti-Thyroglobulin antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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