Rabbit Polyclonal Anti-TMEPAI antibody (STJ98968)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-TMEPAI antibody (STJ98968)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|PMEPA_HUMAN antibody|PMEPA1 antibody|Prostate transmembrane protein, androgen induced 1 antibody|Solid tumor associated 1 protein antibody|Solid tumor-associated 1 protein antibody|STAG1 antibody|TMEPAI antibody|Transmembrane prostate androgen induced protein antibody|Transmembrane prostate androgen-induced protein antibody|Transmembrane, prostate androgen induced RNA antibody|Anti-TMEPAI antibody (ab128006)
SCBT cat No: sc-293372|sc-85829|

Name

Anti-TMEPAI antibody

Catalogue No.

STJ98968

Reactivity

Human

Specificity

Anti-TMEPAI antibody detects endogenous TMEPAI.

Immunogen

Synthetic peptide from human protein at AA range: 240-287.

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

36kDa

Formulation

Anti-TMEPAI antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-TMEPAI antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

PMEPA_HUMAN antibody, PMEPA1 antibody, Prostate transmembrane protein, androgen induced 1 antibody, Solid tumor associated 1 protein antibody, Solid tumor-associated 1 protein antibody, STAG1 antibody, TMEPAI antibody, Transmembrane prostate androgen induced protein antibody, Transmembrane prostate androgen-induced protein antibody, Transmembrane, prostate androgen induced RNA antibody

Database links

UniProt/Swiss-Prot:Q969W9

Protein function

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). .

Protein tissue specificity

Highest expression in prostate. Also expressed in ovary.

Protein sequence and domain

Belongs to the PMEPA1 family. The WW-binding motifs mediate interaction with NEDD4. ; The SMAD interaction motif is required for interaction with SMAD2 and SMAD3 and the negative regulation of TGF-beta signaling.

Protein cellular localization

Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.

Research area

All research areas>Tumor Suppressor/Apoptosis>PMEPA
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize Anti-TMEPAI antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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