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Rabbit Polyclonal Anti-TMEPAI antibody (STJ98968)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-TMEPAI antibody.
Check alternative names for the antibodyExpand
|PMEPA_HUMAN antibody|PMEPA1 antibody|Prostate transmembrane protein, androgen induced 1 antibody|Solid tumor associated 1 protein antibody|Solid tumor-associated 1 protein antibody|STAG1 antibody|TMEPAI antibody|Transmembrane prostate androgen induced protein antibody|Transmembrane prostate androgen-induced protein antibody|Transmembrane, prostate androgen induced RNA antibody|Anti-TMEPAI antibody (ab128006)
SCBT cat No: sc-293372|sc-85829|
|Catalogue No.|| |
Anti-TMEPAI antibody detects endogenous TMEPAI.
Synthetic peptide from human protein at AA range: 240-287.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-TMEPAI antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-TMEPAI antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
PMEPA_HUMAN antibody, PMEPA1 antibody, Prostate transmembrane protein, androgen induced 1 antibody, Solid tumor associated 1 protein antibody, Solid tumor-associated 1 protein antibody, STAG1 antibody, TMEPAI antibody, Transmembrane prostate androgen induced protein antibody, Transmembrane prostate androgen-induced protein antibody, Transmembrane, prostate androgen induced RNA antibody
|Database links|| |
|Protein function|| |
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). .
|Protein tissue specificity|| |
Highest expression in prostate. Also expressed in ovary.
|Protein sequence and domain|| |
Belongs to the PMEPA1 family. The WW-binding motifs mediate interaction with NEDD4. ; The SMAD interaction motif is required for interaction with SMAD2 and SMAD3 and the negative regulation of TGF-beta signaling.
|Protein cellular localization|| |
Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
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St John’s Laboratory Ltd.
|Product type|| |
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