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Rabbit Polyclonal Anti-Versican antibody (STJ98730)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC-P, ELISA
Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Versican antibody.
Check alternative names for the antibodyExpand
SCBT cat No:
|Catalogue No.|| |
Human, Mouse, Rat
Anti-Versican antibody detects endogenous Versican.
Synthetic peptide from human protein at AA range: 2530-2580.
|Recommended dilution|| |
IHC-P 1:50-300; ELISA 1:5000-20000
Anti-Versican antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Anti-Versican antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Database links|| |
|Protein function|| |
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
|Protein tissue specificity|| |
Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.
|Involvement in disease|| |
Wagner vitreoretinopathy (WGVRP) [MIM:143200]: A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. . Note=The disease is caused by mutations affecting the gene represented in this entry. The pathological mechanism involves a quantitave imbalance of the normally occurring splice variants (PubMed:22739342). .
|Protein sequence and domain|| |
Belongs to the aggrecan/versican proteoglycan family. ; Contains 1 C-type lectin domain. ; Contains 2 EGF-like domains. ; Contains 1 Ig-like V-type (immunoglobulin-like) domain. ; Contains 2 Link domains. ; Contains 1 Sushi (CCP/SCR) domain.
|Protein post-translational modifications|| |
Phosphorylated by FAM20C in the extracellular medium. .
|Protein cellular localization|| |
Secreted, extracellular space, extracellular matrix.
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St John’s Laboratory Ltd.
|Product type|| |
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