Rabbit Polyclonal Anti-Versican antibody (STJ98730)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: IHC-P, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-Versican antibody (STJ98730)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC-P, ELISA

Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000

Recommended protocols: check protocols

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SCBT cat No:

Name

Anti-Versican antibody

Catalogue No.

STJ98730

Reactivity

Human, Mouse, Rat

Specificity

Anti-Versican antibody detects endogenous Versican.

Immunogen

Synthetic peptide from human protein at AA range: 2530-2580.

Host

Rabbit

Applications

IHC-P, ELISA

Recommended dilution

IHC-P 1:50-300; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-Versican antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-Versican antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Database links

UniProt/Swiss-Prot:P13611

Protein function

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

Protein tissue specificity

Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.

Involvement in disease

Wagner vitreoretinopathy (WGVRP) [MIM:143200]: A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. . Note=The disease is caused by mutations affecting the gene represented in this entry. The pathological mechanism involves a quantitave imbalance of the normally occurring splice variants (PubMed:22739342). .

Protein sequence and domain

Belongs to the aggrecan/versican proteoglycan family. ; Contains 1 C-type lectin domain. ; Contains 2 EGF-like domains. ; Contains 1 Ig-like V-type (immunoglobulin-like) domain. ; Contains 2 Link domains. ; Contains 1 Sushi (CCP/SCR) domain.

Protein post-translational modifications

Phosphorylated by FAM20C in the extracellular medium. .

Protein cellular localization

Secreted, extracellular space, extracellular matrix.

Note

AntibodyPlus can customize Anti-Versican antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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