Rabbit Polyclonal Anti-VHL antibody (STJ98809)

$99.00$319.00

Reactivity: Human
Applications: IHC-P, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Anti-VHL antibody (STJ98809)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC-P, ELISA

Recommended dilution: IHC-P 1:50-300; ELISA 1:5000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|Elongin binding protein antibody|G7 protein antibody|HRCA 1 antibody|HRCA1 antibody|Protein G7 antibody|pVHL antibody|RCA 1 antibody|RCA1 antibody|VHL 1 antibody|VHL antibody|VHL_HUMAN antibody|VHL1 antibody|VHLH antibody|Von Hippel Lindau disease tumor suppressor antibody|von Hippel Lindau syndrome antibody|von Hippel Lindau tumor suppressor antibody|Von Hippel Lindau tumor suppressor, E3 ubiquitin protein ligase antibody|Von Hippel-Lindau disease tumor suppressor antibody|Anti-Von Hippel Lindau antibody (ab135576)
SCBT cat No:

Name

Anti-VHL antibody

Catalogue No.

STJ98809

Reactivity

Human

Specificity

Anti-VHL antibody detects endogenous VHL.

Immunogen

Synthetic peptide from human protein at AA range: 1-50.

Host

Rabbit

Applications

IHC-P, ELISA

Recommended dilution

IHC-P 1:50-300; ELISA 1:5000-20000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Anti-VHL antibody was tube-contained in PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Concentration

1 mg/ml

Purification

Anti-VHL antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Elongin binding protein antibody, G7 protein antibody, HRCA 1 antibody, HRCA1 antibody, Protein G7 antibody, pVHL antibody, RCA 1 antibody, RCA1 antibody, VHL 1 antibody, VHL antibody, VHL_HUMAN antibody, VHL1 antibody, VHLH antibody, Von Hippel Lindau disease tumor suppressor antibody, von Hippel Lindau syndrome antibody, von Hippel Lindau tumor suppressor antibody, Von Hippel Lindau tumor suppressor, E3 ubiquitin protein ligase antibody, Von Hippel-Lindau disease tumor suppressor antibody

Database links

UniProt/Swiss-Prot:P40337

Protein function

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. .

Protein tissue specificity

Expressed in the adult and fetal brain and kidney.

Involvement in disease

Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; von Hippel-Lindau disease (VHLD) [MIM:193300]: VHLD is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign neoplasms, most frequently retinal, cerebellar and spinal hemangioblastoma, renal cell carcinoma (RCC), pheochromocytoma, and pancreatic tumors. VHL type 1 is without pheochromocytoma, type 2 is with pheochromocytoma. VHL type 2 is further subdivided into types 2A (pheochromocytoma, retinal angioma, and hemangioblastomas without renal cell carcinoma and pancreatic cyst) and 2B (pheochromocytoma, retinal angioma, and hemangioblastomas with renal cell carcinoma and pancreatic cyst). . Note=The disease is caused by mutations affecting the gene represented in this entry.; Erythrocytosis, familial, 2 (ECYT2) [MIM:263400]: An autosomal recessive disorder characterized by an increase in serum red blood cell mass, hypersensitivity of erythroid progenitors to erythropoietin, increased erythropoietin serum levels, and normal oxygen affinity. Patients with ECYT2 carry a high risk for peripheral thrombosis and cerebrovascular events. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the VHL family. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

Protein cellular localization

Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.; Isoform 3: Cytoplasm. Nucleus. Note=Equally distributed between the nucleus and the cytoplasm but not membrane-associated.

Research area

All research areas>Tumor Suppressor/Apoptosis>VHL
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize Anti-VHL antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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