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Rabbit Polyclonal Anti-WIPI2 antibody (STJ98939)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-WIPI2 antibody.
Check alternative names for the antibodyExpand
|ATG18B antibody|Atg21 antibody|CGI 50 antibody|DKFZp434J154 antibody|DKFZp686P02188 antibody|FLJ12979 antibody|FLJ14217 antibody|FLJ42984 antibody|WD repeat domain phosphoinositide-interacting protein 2 antibody|WD repeat domain, phosphoinositide interacting 2 antibody|WD40 repeat protein interacting with phosphoinositides 2 antibody|WIPI 2 antibody|WIPI-2 antibody|WIPI2 antibody|WIPI2_HUMAN antibody|WIPI49 like protein 2 antibody|WIPI49-like protein 2 antibody|Anti-WIPI2 antibody [2A2] (ab105459)
SCBT cat No:
|Catalogue No.|| |
Human, Mouse, Rat
Anti-WIPI2 antibody detects endogenous WIPI2 protein.
Recombinant Protein of WIPI2.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-WIPI2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-WIPI2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ATG18B antibody, Atg21 antibody, CGI 50 antibody, DKFZp434J154 antibody, DKFZp686P02188 antibody, FLJ12979 antibody, FLJ14217 antibody, FLJ42984 antibody, WD repeat domain phosphoinositide-interacting protein 2 antibody, WD repeat domain, phosphoinositide interacting 2 antibody, WD40 repeat protein interacting with phosphoinositides 2 antibody, WIPI 2 antibody, WIPI-2 antibody, WIPI2 antibody, WIPI2_HUMAN antibody, WIPI49 like protein 2 antibody, WIPI49-like protein 2 antibody
|Database links|| |
|Protein function|| |
Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). May bind PtdIns3P. .; Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. .
|Protein tissue specificity|| |
Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. .
|Protein sequence and domain|| |
Belongs to the WD repeat SVP1 family. ; Contains 7 WD repeats. The FRRG motif is required for recruitment to PtdIns3P.
|Protein cellular localization|| |
Preautophagosomal structure membrane ; Peripheral membrane protein ; Cytoplasmic side . Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. .
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St John’s Laboratory Ltd.
|Product type|| |
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