Rabbit polyclonal ANXA2 antibody (A1572)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,RIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal ANXA2 antibody (A1572)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,RIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:20 – 1:50 RIP 1:20 – 1:50

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ANXA2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ANX2 antibody, ANX2L4 antibody, CAL1H antibody, LIP2 antibody, LPC2 antibody, LPC2D antibody, P36 antibody, PAP-IV antibody
Annexin A2 antibody|Annexin II antibody|Annexin II, heavy chain antibody|Annexin-2 antibody|ANX 2 antibody|ANX2 antibody|ANX2L4 antibody|ANXA2 antibody|ANXA2_HUMAN antibody|arylsulfatase B antibody|CAL1H antibody|Calpactin I heavy chain antibody|calpactin I heavy polypeptide (p36) antibody|Calpactin I heavy polypeptide antibody|Calpactin-1 heavy chain antibody|chromobindin 8 antibody|Chromobindin-8 antibody|Epididymis secretory protein Li 270 antibody|HEL S 270 antibody|LIP2 antibody|Lipocortin II antibody|LPC2 antibody|LPC2D antibody|p36 antibody|P36 protein antibody|PAP-IV antibody|Placental anticoagulant protein IV antibody|Protein I antibody|Anti-Annexin A2 antibody (ab41803)

SCBT cat No: sc-47696|sc-30757|sc-28385|sc-1924|sc-65873|sc-166762|sc-271175|sc-48397|sc-9061|sc-101511|sc-134260|

Name

Rabbit polyclonal ANXA2 antibody

Catalogue No.

A1572

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ANXA2

Host

Rabbit

Applications

WB, IHC, IF, IP, RIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:20 – 1:50
RIP 1:20 – 1:50

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 39kDa/Observed: Refer to Figures

Formulation

ANXA2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ANXA2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ANX2 antibody, ANX2L4 antibody, CAL1H antibody, LIP2 antibody, LPC2 antibody, LPC2D antibody, P36 antibody, PAP-IV antibody

Database links

Human UniProt/Swiss-Prot:P07355

Protein names

ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV

Protein function

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 .

Protein sequence and domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.Belongs to the annexin family.; Contains 4 annexin repeats.

Protein post-translational modifications

Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.; ISGylated.

Protein cellular localization

Secreted, extracellular space, extracellular matrix, basement membrane . Melanosome . Note: In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.

Background

Annexin A2 (ANXA2), also known as lipocortin II or calpactin-1 heavy chain, is a 36 kDa member of the annexin superfamily that binds phospholipids and other proteins in a calcium-dependent manner via annexin repeats (1). Annexin A2 contains four such repeats through which it mediates protein-protein and protein-lipid interactions (1-4). It forms a constitutive heterotetramer with S100A10, acting as a bridge between the actin cytoskeleton, plasma membrane, and endocytotic vesicle machinery (5-7). Originally identified as a protein inhibitor of phospholipase A2, annexin A2 has subsequently been shown to interact with an array of protein and non-protein partners, including F-actin, spectrin, SNARE complexes, RNA, and virus particles (4,6,8,9). Annexin A2 has also been shown to have receptor-like activity and is detected on the surface of macrophages and vascular endothelial cells where it mediates macrophage activation and Factor Xa signaling, respectively (10-13). Upregulation of annexin A2 at the cell surface is thought to be modulated by phosphorylation at Tyr23 by Src (14-18). Interestingly, phosphorylation at Tyr23 has recently been shown to be required for cell surface expression of annexin A2 where it mediates motility, invasiveness, and overall metastatic potential of certain pancreatic cancer cells (19,20).

Research area

All research areas>Signaling Intermediates>Annexin
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize ANXA2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!