Rabbit polyclonal ANXA5 antibody (A1728)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ANXA5 antibody (A1728)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ANXA5 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ANX5 antibody, ENX2 antibody, PP4 antibody
Anchorin CII antibody|Annexin 5 antibody|Annexin A5 antibody|Annexin V antibody|Annexin-5 antibody|ANX A5 antibody|ANX5 antibody|ANXA5 antibody|ANXA5_HUMAN antibody|Calphobindin I antibody|CBP-I antibody|Endonexin II antibody|ENX2 antibody|Lipocortin V antibody|PAP I antibody|PAP-I antibody|Placental anticoagulant protein 4 antibody|Placental anticoagulant protein I antibody|PLACENTAL PROTEIN 4 antibody|Pp4 antibody|Thromboplastin inhibitor antibody|VAC-alpha antibody|Vascular anticoagulant-alpha antibody|Anti-Annexin V antibody (ab14196)

SCBT cat No: sc-32321|sc-393669|sc-1928|sc-271015|sc-8300|sc-74438|sc-1929|

Name

Rabbit polyclonal ANXA5 antibody

Catalogue No.

A1728

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ANXA5

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 36kDa/Observed: Refer to Figures

Formulation

ANXA5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ANXA5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ANX5 antibody, ENX2 antibody, PP4 antibody

Database links

Human UniProt/Swiss-Prot:P08758

Protein names

ANX5, ENX2, PP4

Protein function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Protein sequence and domain

The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.; A pair of annexin repeats may form one binding site for calcium and phospholipid.Belongs to the annexin family.; Contains 4 annexin repeats.

Protein post-translational modifications

S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.

Background

Annexin V, also known as PAP-1 or Lipocortin V, is a ~30 kDa protein that binds to phospholipids in a calcium-dependent manner (1). All annexins contain a putative PKC binding site, but only annexin V has been identified as an inhibitor of this pathway (2). It may also signal, by direct interaction withVEGFR2 receptor, in the regulation of vascular endothelial cell proliferation (3). Annexin V preferentially binds phosphatidylserine, in competition with prothrombin, leading to inhibition of blood coagulation at sites of injury preceding contact between lipid components and coagulation factors thatinitiate thrombosis (4-6). The ability of Annexin V to bind specifically and robustly to hosphatidylserine makes it an attractive reagent in detecting apoptotic cells (7). Annexin V is inducible by glucocorticoids and can be phosphorylated by tyrosine and serine/threonine kinases (8). It isthought toblockproduction of mediators of inflammation, such as prostaglandins and leukotrienes by inhibiting the release of arachidonic acid from membranes by phospholipase A2 (8).

Research area

All research areas>Signaling Intermediates>Annexin
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize ANXA5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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