Rabbit polyclonal APITD1 antibody (A8293)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal APITD1 antibody (A8293)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal APITD1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

MHF1 antibody, CENPS antibody, CENP-S antibody, FAAP16 antibody
APITD1 antibody|Apoptosis-inducing TAF9-like domain-containing protein 1 antibody|apoptosis-inducing, TAF9-like domain 1 antibody|CENP-S antibody|CENPS antibody|CENPS_HUMAN antibody|Centromere protein S antibody|FAAP16 antibody|FANCM-interacting histone fold protein 1 antibody|Fanconi anemia-associated polypeptide of 16 kDa antibody|MGC32686 antibody|MHF 1 antibody|Anti-MHF1 antibody (ab169385)

SCBT cat No:

Name

Rabbit polyclonal APITD1 antibody

Catalogue No.

A8293

Reactivity

Human

Immunogen

Recombinant protein of human APITD1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 16kDa/Observed: Refer to figures

Formulation

APITD1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

APITD1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MHF1 antibody, CENPS antibody, CENP-S antibody, FAAP16 antibody

Database links

Human UniProt/Swiss-Prot:Q8N2Z9

Protein names

MHF1, CENPS, CENP-S, FAAP16

Protein function

DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.

Protein tissue specificity

Ubiquitously expressed.

Protein sequence and domain

Belongs to the TAF9 family. CENPS subfamily.

Protein cellular localization

Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . Note: Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis .

Background

This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7.

Note

AntibodyPlus can customize APITD1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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