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Rabbit polyclonal APLP1 antibody (A6870)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal APLP1 antibody.
Check alternative names for the antibodyExpand
AMYLOID BETA A4 PRECURSOR-LIKE PROTEIN 1 antibody|AMYLOID PRECURSOR-LIKE PROTEIN antibody|Amyloid-like protein 1 precursor antibody|APLP 1 antibody|APLP antibody|APLP-1 antibody|Aplp1 antibody|APLP1_HUMAN antibody|C30 antibody|Anti-APLP1 antibody – N-terminal (ab191066)
SCBT cat No: sc-367468|sc-23818|
Rabbit polyclonal APLP1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human APLP1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 72kDa/Observed: Refer to figures
APLP1 antibody was tube-contained.
APLP1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.; The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
|Protein tissue specificity|| |
Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
|Protein sequence and domain|| |
The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis.Belongs to the APP family.
|Protein post-translational modifications|| |
Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity).; N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein.; C30: Cytoplasm. Note: C-terminally processed in the Golgi complex.
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
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|Product type|| |
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