Rabbit polyclonal APPL1 antibody (A4606)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal APPL1 antibody (A4606)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal APPL1 antibody.

Alternative names:

Check alternative names for the antibody

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APPL antibody, DIP13alpha antibody
Adapter protein containing PH domain antibody|Adaptor Protein Containing pH Domain antibody|Adaptor protein containing pH domain PTB domain and leucine zipper motif 1 antibody|Adaptor protein containing pH domain PTB domain and leucine zipper motif antibody|AKT2 INTERACTOR antibody|APPL 1 antibody|Appl1 antibody|DCC interacting protein 13 alpha antibody|DCC-interacting protein 13-alpha antibody|DIP 13 alpha antibody|DIP13 alpha antibody|Dip13-alpha antibody|DIP13alpha antibody|DP13A_HUMAN antibody|KIAA1428 antibody|PTB domain and leucine zipper motif 1 antibody|PTB Domain and Leucine Zipper Motif antibody|Signaling adaptor protein DIP13alpha antibody|Anti-APPL antibody (ab59592)

SCBT cat No: sc-271901|sc-55063|sc-271909|sc-67402|sc-55065|

Name

Rabbit polyclonal APPL1 antibody

Catalogue No.

A4606

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human APPL1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 80kDa/Observed: Refer to figures

Formulation

APPL1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

APPL1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

APPL antibody, DIP13alpha antibody

Database links

Human UniProt/Swiss-Prot:Q9UKG1

Protein names

APPL, DIP13alpha

Protein function

Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway.

Protein tissue specificity

High levels in heart, ovary, pancreas and skeletal muscle.

Protein sequence and domain

Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.; The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B.Contains 1 PH domain.; Contains 1 PID domain.

Protein post-translational modifications

Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL.

Protein cellular localization

Early endosome membrane; Peripheral membrane protein. Nucleus. Note: Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.

Background

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Research area

All research areas>Cell Cycle Proteins>APPL
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize APPL1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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