Rabbit polyclonal APTX antibody (A5364)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal APTX antibody (A5364)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

AOA antibody, AOA1 antibody, AXA1 antibody, EAOH antibody, EOAHA antibody, FHA-HIT antibody
AOA 1 antibody|AOA antibody|AOA1 antibody|Aprataxin antibody|Aprataxin homolog antibody|Aptx antibody|APTX_HUMAN antibody|Ataxia 1 early onset with hypoalbuminemia antibody|Ataxia1 early onset with hypoalbuminemia antibody|AXA 1 antibody|AXA1 antibody|EAOH antibody|EOAHA antibody|FHA HIT antibody|FHA-HIT antibody|FLJ20157 antibody|Forkhead associated domain histidine triad like antibody|Forkhead associated domain histidine triad like protein antibody|Forkhead-associated domain histidine triad-like protein antibody|MGC1072 antibody|Anti-Aprataxin antibody [EPR8751] (ab192598)

SCBT cat No: sc-374108|sc-365849|sc-393648|sc-48841|sc-98894|

Name

Rabbit polyclonal APTX antibody

Catalogue No.

A5364

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human APTX

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 41kDa/Observed: Refer to Figures

Formulation

APTX antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

APTX antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

AOA antibody, AOA1 antibody, AXA1 antibody, EAOH antibody, EOAHA antibody, FHA-HIT antibody

Database links

Human UniProt/Swiss-Prot:Q7Z2E3

Protein names

AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT

Protein function

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5′-phosphate termini, resulting in the production of 5′-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5′-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.

Protein tissue specificity

Widely expressed. In brain, it is expressed in the posterior cortex, cerebellum, hippocampus and olfactory bulb. Isoform 1 is highly expressed in the cerebral cortex and cerebellum, compared to isoform 2.

Protein sequence and domain

The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.; The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4.; The HIT domain is required for enzymatic activity.; The C2H2-type zinc finger mediates DNA-binding.Contains 1 C2H2-type zinc finger.; Contains 1 FHA-like domain.; Contains 1 HIT domain.

Protein cellular localization

Nucleus, nucleoplasm. Nucleus, nucleolus. Note: Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization.; Isoform 12: Cytoplasm.

Background

This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.

Note

AntibodyPlus can customize APTX antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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