Rabbit Polyclonal ARAP1 antibody (A10466)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal ARAP1 antibody (A10466)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CENTD2 antibody;
2410002L19Rik antibody|ANK repeat and PH domain-containing protein 1 antibody|ARAP 1 antibody|Arap1 antibody|ARAP1_HUMAN antibody|Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domains containing protein 1 antibody|Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1 antibody|Arf-GAP with Rho-GAP domain antibody|CENT D2 antibody|Centaurin delta 2 antibody|Centaurin delta2 antibody|Centaurin-delta-2 antibody|CENTD 2 antibody|CENTD2 antibody|Cnt d2 antibody|Cnt-d2 antibody|Cntd2 antibody|KIAA0782 antibody|MGC176140 antibody|mKIAA0782 antibody|Anti-ARAP1 antibody (ab5912)

SCBT cat No: sc-393138|

Name

Rabbit Polyclonal ARAP1 antibody

Catalogue No.

A10466

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ARAP1

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

160kDa

Formulation

ARAP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CENTD2 antibody;

Protein names

CENTD2;

Protein function

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).

Protein tissue specificity

Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.

Protein sequence and domain

Contains 1 Arf-GAP domain.; Contains 4 PH domains.; Contains 1 Ras-associating domain.; Contains 1 Rho-GAP domain.; Contains 1 SAM (sterile alpha motif) domain.

Protein cellular localization

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.

Background

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize ARAP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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