Rabbit polyclonal ARF6 antibody (A0988)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ARF6 antibody (A0988)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ARF6 antibody,DKFZp564M0264 antibody
antibody|BING 2 antibody|BING2 antibody|CENP-C binding protein antibody|DAP 6 antibody|DAP6 antibody|DAXX antibody|DAXX_HUMAN antibody|Death associated protein 6 antibody|Death domain associated protein 6 antibody|Death domain associated protein antibody|Death domain-associated protein 6 antibody|EAP 1 antibody|EAP1 antibody|ETS1 associated protein 1 antibody|ETS1-associated protein 1 antibody|Fas binding protein antibody|Fas death domain associated protein antibody|Fas death domain-associated protein antibody|hDaxx antibody|MGC126245 antibody|MGC126246 antibody|Anti-ARF6 antibody (ab77581)

SCBT cat No: sc-7971|

Name

Rabbit polyclonal ARF6 antibody

Catalogue No.

A0988

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ARF6

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 20kDa/Observed: Refer to Figures

Formulation

ARF6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ARF6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ARF6 antibody,DKFZp564M0264 antibody

Database links

Human UniProt/Swiss-Prot:P62330

Protein names

ARF6,DKFZp564M0264

Protein function

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.

Protein tissue specificity

Ubiquitous, with higher levels in heart, substantia nigra, and kidney.

Protein sequence and domain

Belongs to the small GTPase superfamily. Arf family.

Protein cellular localization

Golgi apparatus. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane ; Lipid-anchor . Cell projection, filopodium membrane; Lipid-anchor. Midbody . Cytoplasm . Cleavage furrow . Note: Distributed throughout the cytoplasm during metaphase. Transiently detected at the ingressing cleavage furrow during mitotic cytokinesis. Recruited to the midbody at later stages of cytokinesis; this requires interaction with KIF23 (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles.

Background

ADP-ribosylation factor (Arf) proteins are low molecular weight GTP binding proteins that belong to the Ras GTPase superfamily (1). Arf proteins are grouped into three distinct classes based on amino acid sequence and structural similarity, with Arf6 as the single class III protein to date. Arf6 is localized mainly to the plasma membrane and endosomes (1,2). This small GTPase interacts with PIP5K, PLD and Rac1, proteins important in lipid metabolism and actin regulation. Arf6 function depends upon its cycling between GDP- and GTP-bound states, which is regulated by associated GAP and GEF factors (3,4). Plasma membrane-associated Arf6 appears to play several functions during the many steps of membrane trafficking, including regulating membrane receptor internalization in both clathrin-dependent and independent pathways, endosomal recycling, and proximal actin reorganization and remodeling (5,6).

Research area

All research areas>GDP/GTP Binding Proteins>ARF
(View all antibody categories related to GDP/GTP Binding Proteins)

Note

AntibodyPlus can customize ARF6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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