Rabbit polyclonal ARHGDIA antibody (A1214)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ARHGDIA antibody (A1214)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ARHGDIA antibody,GDIA1 antibody,MGC117248 antibody,RHOGDI antibody,RHOGDI-1 antibody
ARHGDIA antibody|fa96g11 antibody|GDIA 1 antibody|GDIA1 antibody|GDIR1_HUMAN antibody|MGC117248 antibody|NPHS8 antibody|Rho GDI 1 antibody|Rho GDI alpha antibody|Rho GDI antibody|Rho GDP dissociation inhibitor (GDI) alpha antibody|Rho GDP dissociation inhibitor 1 antibody|Rho GDP dissociation inhibitor alpha antibody|Rho GDP-dissociation inhibitor 1 antibody|Rho-GDI alpha antibody|RhoGDI 1 antibody|RhoGDI alpha antibody|RHOGDI antibody|RhoGDI1 antibody|wu:fa96g11 antibody|zgc:55554 antibody|zgc:77681 antibody|Anti-RhoGDI antibody [EPR3773] (ab133248)

SCBT cat No: sc-33047|sc-293143|sc-293144|sc-293145|sc-514033|sc-101793|sc-54279|sc-86799|sc-86801|sc-69225|sc-393034|

Name

Rabbit polyclonal ARHGDIA antibody

Catalogue No.

A1214

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ARHGDIA

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 28kDa/Observed: Refer to Figures

Formulation

ARHGDIA antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ARHGDIA antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ARHGDIA antibody,GDIA1 antibody,MGC117248 antibody,RHOGDI antibody,RHOGDI-1 antibody

Database links

Human UniProt/Swiss-Prot:P52565

Protein names

ARHGDIA,GDIA1,MGC117248,RHOGDI,RHOGDI-1

Protein function

Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.

Protein sequence and domain

Belongs to the Rho GDI family.

Protein cellular localization

Cytoplasm .

Background

Rho family small GTPases, including Rho, Rac and cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. A third level of regulation is provided by the stoichiometric binding of Rho GDP dissociation inhibitor (RhoGDI). RhoGDI affects Rho activity by inhibiting nucleotide exchange and membrane association, regulating activity and localization (Reviewed in 1, 2). The inhibitory and shuttling functions of RhoGDI have been uncoupled using mutant forms of RhoGDI (3). Phosphorylation of GDIs and/or GTPases can modulate their affinity for each other and, therefore, GTPase mediated signaling. PAK1 phosphorylation of RhoGDI at serines 101 and 174 causes release and activation of Rac1, but not RhoA (4).

Research area

All research areas>GDP/GTP Binding Proteins>Rho GDI
(View all antibody categories related to GDP/GTP Binding Proteins)

Note

AntibodyPlus can customize ARHGDIA antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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